PMID- 22276574
OWN - NLM
STAT- MEDLINE
DCOM- 20120913
LR  - 20120628
IS  - 1557-7430 (Electronic)
IS  - 1044-5498 (Linking)
VI  - 31
IP  - 6
DP  - 2012 Jun
TI  - The association of monocyte chemotactic protein-1 and CC chemokine receptor 2 
      gene variants with chronic obstructive pulmonary disease.
PG  - 1058-63
LID - 10.1089/dna.2011.1520 [doi]
AB  - Chemokines are potent proinflammatory cytokines that are implicated in numerous 
      inflammatory diseases. Monocyte chemoattractant protein-1 (MCP-1) and its 
      receptor CC chemokine receptor-2 (CCR2) play a major role in the recruitment of 
      inflammatory cells to the lungs of patients with chronic obstructive pulmonary 
      disease (COPD). We investigated a possible association between polymorphisms in 
      MCP-1 and CCR2 genes (MCP-1 -2518 A/G and CCR2 190G/A or V64I) and the 
      development of COPD. Genotypes were determined by polymerase chain 
      reaction-restriction fragment length polymorphism in 386 COPD cases and 398 
      age-matched healthy controls. Frequency of MCP-1 2518GG genotype for cases and 
      controls was 0.396 and 0.324, respectively; individuals who had the GG genotype 
      had a 1.59-fold increased risk of COPD (p=0.036). Frequency of CCR2 190AA 
      (64I/64I) genotype for cases and controls was 0.285 and 0.21, respectively; 
      subjects carrying the 64I/64I genotype had a 2.04-fold increased risk of COPD 
      compared with the wild-type genotype (p=0.001). When analyzing the allele 
      combination of these two polymorphisms, the combinations MCP-1-A/CCR2-A and 
      MCP-1-G/CCR2-A were detected in significantly higher numbers in COPD cases than 
      in healthy controls (odds ratio [OR]=1.50, 95% confidence interval [CI]: 
      1.04-2.17, p=0.032; and OR=1.89, 95% CI: 1.38-2.60, p=7.38x10(-5)). These data 
      suggest that MCP-1 -2518 A/G and CCR2 190G/A polymorphisms are new risk factors 
      for COPD.
FAU - Bai, Jianwen
AU  - Bai J
AD  - Emergency Center, Shanghai East Hospital, Shanghai, China.
FAU - Song, Haihan
AU  - Song H
FAU - Cai, Chen
AU  - Cai C
FAU - Zhang, Meiyan
AU  - Zhang M
FAU - Xu, Shumin
AU  - Xu S
FAU - Tan, Jun
AU  - Tan J
LA  - eng
PT  - Journal Article
DEP - 20120125
PL  - United States
TA  - DNA Cell Biol
JT  - DNA and cell biology
JID - 9004522
RN  - 0 (Chemokine CCL2)
RN  - 0 (Ligands)
RN  - 0 (Receptors, CCR2)
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - Chemokine CCL2/*genetics/metabolism
MH  - Female
MH  - Humans
MH  - Ligands
MH  - Male
MH  - *Polymorphism, Genetic
MH  - Pulmonary Disease, Chronic Obstructive/*genetics
MH  - Receptors, CCR2/*genetics/metabolism
EDAT- 2012/01/27 06:00
MHDA- 2012/09/14 06:00
CRDT- 2012/01/27 06:00
PHST- 2012/01/27 06:00 [entrez]
PHST- 2012/01/27 06:00 [pubmed]
PHST- 2012/09/14 06:00 [medline]
AID - 10.1089/dna.2011.1520 [doi]
PST - ppublish
SO  - DNA Cell Biol. 2012 Jun;31(6):1058-63. doi: 10.1089/dna.2011.1520. Epub 2012 Jan 
      25.