PMID- 22276679
OWN - NLM
STAT- MEDLINE
DCOM- 20120423
LR  - 20240109
IS  - 1520-6025 (Electronic)
IS  - 0163-3864 (Linking)
VI  - 75
IP  - 2
DP  - 2012 Feb 24
TI  - Bioactive hydroanthraquinones and anthraquinone dimers from a soft coral-derived 
      Alternaria sp. fungus.
PG  - 189-97
LID - 10.1021/np200766d [doi]
AB  - Five new hydroanthraquinone derivatives, tetrahydroaltersolanols C-F (1-4) and 
      dihydroaltersolanol A (5), and five new alterporriol-type anthranoid dimers, 
      alterporriols N-R (12-16), along with seven known analogues (6-11 and 17), were 
      isolated from the culture broth and the mycelia of Alternaria sp. ZJ-2008003, a 
      fungus obtained from a Sarcophyton sp. soft coral collected from the South China 
      Sea. Their structures and the relative configurations were elucidated using 
      comprehensive spectroscopic methods including 1D and 2D NOE spectra as well as 
      single-crystal X-ray crystallography. Compound 13 represents the first isolated 
      alterporriol dimer with a C-4-C-4' linkage, and the absolute configuration of 4 
      was determined using the modified Mosher's method. Compounds 1 and 15 exhibited 
      antiviral activity against the porcine reproductive and respiratory syndrome 
      virus (PRRSV), with IC(5)(0) values of 65 and 39 muM, respectively. Compound 14 showed 
      cytotoxic activity against PC-3 and HCT-116 cell lines, with IC(5)(0) values of 6.4 
      and 8.6 muM, respectively.
FAU - Zheng, Cai-Juan
AU  - Zheng CJ
AD  - Key Laboratory of Marine Drugs, The Ministry of Education of China, School of 
      Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's 
      Republic of China.
FAU - Shao, Chang-Lun
AU  - Shao CL
FAU - Guo, Zhi-Yong
AU  - Guo ZY
FAU - Chen, Jian-Feng
AU  - Chen JF
FAU - Deng, Dong-Sheng
AU  - Deng DS
FAU - Yang, Kai-Lin
AU  - Yang KL
FAU - Chen, Yi-Yan
AU  - Chen YY
FAU - Fu, Xiu-Mei
AU  - Fu XM
FAU - She, Zhi-Gang
AU  - She ZG
FAU - Lin, Yong-Cheng
AU  - Lin YC
FAU - Wang, Chang-Yun
AU  - Wang CY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120125
PL  - United States
TA  - J Nat Prod
JT  - Journal of natural products
JID - 7906882
RN  - 0 (Anthraquinones)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Antineoplastic Agents)
RN  - 030MS0JBDO (9,10-anthraquinone)
SB  - IM
MH  - Alternaria/*chemistry
MH  - Animals
MH  - Anthozoa/microbiology
MH  - Anthraquinones/chemistry/*isolation & purification/*pharmacology
MH  - Anti-Bacterial Agents/chemistry/*isolation & purification/*pharmacology
MH  - Antineoplastic Agents/chemistry/*isolation & purification/*pharmacology
MH  - Drug Screening Assays, Antitumor
MH  - HCT116 Cells
MH  - Humans
MH  - Inhibitory Concentration 50
MH  - Microbial Sensitivity Tests
MH  - Molecular Structure
MH  - Nuclear Magnetic Resonance, Biomolecular
EDAT- 2012/01/27 06:00
MHDA- 2012/04/24 06:00
CRDT- 2012/01/27 06:00
PHST- 2012/01/27 06:00 [entrez]
PHST- 2012/01/27 06:00 [pubmed]
PHST- 2012/04/24 06:00 [medline]
AID - 10.1021/np200766d [doi]
PST - ppublish
SO  - J Nat Prod. 2012 Feb 24;75(2):189-97. doi: 10.1021/np200766d. Epub 2012 Jan 25.