PMID- 22277318
OWN - NLM
STAT- MEDLINE
DCOM- 20120625
LR  - 20190819
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 76
IP  - 4
DP  - 2012
TI  - Outcome of pregnancy and effects on the right heart in women with repaired 
      tetralogy of fallot.
PG  - 957-63
AB  - BACKGROUND: Improved medical techniques have allowed most women with repaired 
      tetralogy of Fallot (TOF) to reach childbearing age. The predictors of adverse 
      events and the effects of pregnancy on cardiac function have not been clearly 
      described in these patients. METHODS AND RESULTS: In the present study we 
      retrospectively reviewed 40 deliveries in 25 patients with repaired TOF. There 
      were 23 patients in New York Heart Association (NYHA) class I, and 2 in classes 
      II-III before pregnancy. The mean age at delivery was 29.1 years and the mean 
      gestational period was 37.8 weeks. Seven pregnancies (17.5%) in 7 patients were 
      complicated with cardiac events such as a decline in NYHA class and arrhythmia. 
      History of ablation and the baseline cardiothoracic ratio on chest radiography 
      were predictors of adverse events. Peak plasma brain natriuretic peptide (BNP) 
      level after the second trimester was higher in patients with cardiac events. Left 
      ventricular size and contraction did not change from before to after pregnancy, 
      but the right ventricle was enlarged at 6 months after delivery. CONCLUSIONS: 
      Many of the pregnancies in women with repaired TOF were successful. However, 
      careful management is required for some patients and the BNP level may be a 
      useful marker to identify these patients. Because the right heart tended to be 
      enlarged in the late postpartum period, pregnancy may also affect the long-term 
      prognosis of patients with repaired TOF.
FAU - Kamiya, Chizuko A
AU  - Kamiya CA
AD  - Department of Perinatology and Gynecology, National Cerebral and Cardiovascular 
      Center, Suita, Japan. chiz@hsp.ncvc.go.jp
FAU - Iwamiya, Tadashi
AU  - Iwamiya T
FAU - Neki, Reiko
AU  - Neki R
FAU - Katsuragi, Shinji
AU  - Katsuragi S
FAU - Kawasaki, Kaoru
AU  - Kawasaki K
FAU - Miyoshi, Takakazu
AU  - Miyoshi T
FAU - Sasaki, Yoshihito
AU  - Sasaki Y
FAU - Osato, Kazuhiro
AU  - Osato K
FAU - Murohara, Toyoaki
AU  - Murohara T
FAU - Ikeda, Tomoaki
AU  - Ikeda T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120125
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - 0 (Biomarkers)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Cardiac Surgical Procedures/*adverse effects
MH  - Chi-Square Distribution
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - Hypertrophy, Right Ventricular/blood/diagnosis/*etiology/physiopathology
MH  - Japan
MH  - Natriuretic Peptide, Brain/blood
MH  - Pregnancy
MH  - Pregnancy Complications, Cardiovascular/blood/diagnosis/*etiology/physiopathology
MH  - *Pregnancy Outcome
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Tetralogy of Fallot/*surgery
MH  - Time Factors
EDAT- 2012/01/27 06:00
MHDA- 2012/06/26 06:00
CRDT- 2012/01/27 06:00
PHST- 2012/01/27 06:00 [entrez]
PHST- 2012/01/27 06:00 [pubmed]
PHST- 2012/06/26 06:00 [medline]
AID - JST.JSTAGE/circj/CJ-11-1239 [pii]
AID - 10.1253/circj.cj-11-1239 [doi]
PST - ppublish
SO  - Circ J. 2012;76(4):957-63. doi: 10.1253/circj.cj-11-1239. Epub 2012 Jan 25.