PMID- 22277344
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220311
IS  - 1743-7075 (Electronic)
IS  - 1743-7075 (Linking)
VI  - 9
IP  - 1
DP  - 2012 Jan 25
TI  - High prevalence of gastroesophageal reflux symptoms in type 2 diabetics with 
      hypoadiponectinemia and metabolic syndrome.
PG  - 4
LID - 10.1186/1743-7075-9-4 [doi]
AB  - BACKGROUND: The prevalence of gastroesophageal reflux disease (GERD) has been 
      increasing worldwide. Abdominal obesity or visceral fat accumulation rather than 
      simple obesity is associated with GERD. Previous reports demonstrated the 
      association between GERD and type 2 diabetes mellitus (T2DM). Signification of 
      visceral fat accumulation and adiponectin in T2DM patients with GERD remains 
      unclear. The present study investigated the relationships between GERD symptoms, 
      visceral fat accumulation and adiponectin in subjects with T2DM. FINDINGS: The 
      study (ADMIT study) subjects were 66 Japanese T2DM outpatients, who answered the 
      questionnaire regarding GERD symptoms in Frequency Scale for the Symptoms of GERD 
      (FSSG), and were measured visceral fat area by bioelectrical impedance analysis. 
      Patients with FSSG scores of more than 8 were considered as positive. The 
      prevalence of FSSG score >/= 8 and average FSSG score in T2DM subjects with the 
      metabolic syndrome (Mets) were significantly higher compared to those without 
      Mets. The prevalence of FSSG score >/= 8 and average FSSG score in T2DM subjects 
      with low levels of serum adiponectin were significantly higher compared to those 
      with high levels of serum adiponectin. Moreover, the combination of Mets and 
      hypoadiponectinemia had a multiplicative effect on GERD symptom score (p = 
      0.047). CONCLUSIONS: Our study showed that the coexistence of MetS and low levels 
      of serum adiponectin was associated with the higher prevalence of FSSG score >/= 8 
      and the higher scores of GERD symptom in subjects with T2DM. TRIAL REGISTRATION: 
      UMIN 000002271.
FAU - Hirata, Ayumu
AU  - Hirata A
AD  - Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 
      Suita, Osaka 565-0871, Japan. kkishida@imed2.med.osaka-u.ac.jp.
FAU - Kishida, Ken
AU  - Kishida K
FAU - Nakatsuji, Hideaki
AU  - Nakatsuji H
FAU - Inoue, Kana
AU  - Inoue K
FAU - Hiuge-Shimizu, Aki
AU  - Hiuge-Shimizu A
FAU - Funahashi, Tohru
AU  - Funahashi T
FAU - Shimomura, Iichiro
AU  - Shimomura I
LA  - eng
PT  - Journal Article
DEP - 20120125
PL  - England
TA  - Nutr Metab (Lond)
JT  - Nutrition & metabolism
JID - 101231644
PMC - PMC3293023
EDAT- 2012/01/27 06:00
MHDA- 2012/01/27 06:01
PMCR- 2012/01/25
CRDT- 2012/01/27 06:00
PHST- 2011/12/21 00:00 [received]
PHST- 2012/01/25 00:00 [accepted]
PHST- 2012/01/27 06:00 [entrez]
PHST- 2012/01/27 06:00 [pubmed]
PHST- 2012/01/27 06:01 [medline]
PHST- 2012/01/25 00:00 [pmc-release]
AID - 1743-7075-9-4 [pii]
AID - 10.1186/1743-7075-9-4 [doi]
PST - epublish
SO  - Nutr Metab (Lond). 2012 Jan 25;9(1):4. doi: 10.1186/1743-7075-9-4.