PMID- 22277475
OWN - NLM
STAT- MEDLINE
DCOM- 20120918
LR  - 20190918
IS  - 1882-0654 (Electronic)
IS  - 0009-918X (Linking)
VI  - 51
IP  - 11
DP  - 2011 Nov
TI  - [Progressive multifocal leukoencephalopathy (PML)].
PG  - 1051-7
AB  - Progressive multifocal leukoencephalopathy (PML) is caused by reactivation of 
      latently infected JCV when hosts' immune system is impaired by HIV infection, 
      hematologic diseases, collagen diseases, immunemodulatory therapy and so on. PML 
      was rare but HIV infection and Natalizumab have made it much more common while 
      the prognosis is much better than other PML. PML patients present with various 
      signs and symptoms including hemiparesis, dementia, aphasia, visual disturbance, 
      cranial nerve paresis, cerebellar signs and bladder bowel disturbance. Brain MRI 
      reveals characteristic demyelinating lesions in the CNS white matter and CSF mild 
      increase of protein with or without mild mononuclear pleocytosis. Detection of 
      JCV genome from CSF is crucial for the clinical diagnosis of PML. PML was once 
      thought to be fatal but some HIV infected PML patients showed halting progression 
      or even recovery after introduction of HAART. In addition, anti-malarial drug 
      mefloquine was found to be effective. Recovery of immunity may provoke some 
      inflammatory responses known as immune reconstruction inflammatory syndrome 
      (IRIS) which requires high dose corticosteroid. In Japan, we are providing free 
      test of CSF-JCV genome and organized a unique system for surveillance and 
      clinical research of PML. Using this system we hope to improve diagnosis and 
      therapy of PML in Japan.
FAU - Mizusawa, Hidehiro
AU  - Mizusawa H
AD  - Department of Neurology, Tokyo Medical and Dental University, Graduate School of 
      Medical and Dental Sciences.
FAU - Kishida, Shuji
AU  - Kishida S
FAU - Saijo, Masayuki
AU  - Saijo M
FAU - Yukishita, Motohiro
AU  - Yukishita M
FAU - Shishido-Hara, Yukiko
AU  - Shishido-Hara Y
FAU - Sawa, Hirohumi
AU  - Sawa H
FAU - Nagashima, Kazuo
AU  - Nagashima K
FAU - Nukuzuma, Souichi
AU  - Nukuzuma S
FAU - Yamada, Masahito
AU  - Yamada M
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Rinsho Shinkeigaku
JT  - Rinsho shinkeigaku = Clinical neurology
JID - 0417466
SB  - IM
MH  - Humans
MH  - *Leukoencephalopathy, Progressive Multifocal/drug therapy/pathology
EDAT- 2012/01/27 06:00
MHDA- 2012/09/19 06:00
CRDT- 2012/01/27 06:00
PHST- 2012/01/27 06:00 [entrez]
PHST- 2012/01/27 06:00 [pubmed]
PHST- 2012/09/19 06:00 [medline]
AID - JST.JSTAGE/clinicalneurol/51.1051 [pii]
AID - 10.5692/clinicalneurol.51.1051 [doi]
PST - ppublish
SO  - Rinsho Shinkeigaku. 2011 Nov;51(11):1051-7. doi: 10.5692/clinicalneurol.51.1051.