PMID- 22278770
OWN - NLM
STAT- MEDLINE
DCOM- 20120514
LR  - 20211021
IS  - 1534-6269 (Electronic)
IS  - 1523-3790 (Linking)
VI  - 14
IP  - 2
DP  - 2012 Apr
TI  - The clinical importance of quality-of-life scores in patients with skull base 
      tumors: a meta-analysis and review of the literature.
PG  - 175-81
LID - 10.1007/s11912-012-0222-3 [doi]
AB  - Health-related quality of life (QOL) outcomes are frequently used by clinicians, 
      patients, and researchers for assessing the effectiveness of an intervention. 
      Small differences in QOL may be statistically significant but their clinical 
      relevance remains undefined. The smallest changes in QOL scores of the anterior 
      skull base surgery questionnaire (ASBS-Q) which could be considered clinically 
      significant have not been delineated. Here we present a meta analysis and review 
      of the literature of 273 patients undergoing skull base tumor resection. The 
      minimal clinically important difference (MCID), defined as "the smallest change 
      in QOL which patients perceive as beneficial", was calculated using several 
      statistical approaches. The MCID of the ASBS-Q was 0.4 (8%, score range 1-5). 
      Various other instruments for QOL estimations revealed a larger range of MCID 
      score (between 6.2%-17.5%) for the different QOL domains. The statistical 
      analyses reveal that histology (benign vs malignant), time elapsed from surgery 
      (< or >/=6 months), and surgical approach (open vs endoscopic) have significant 
      clinical impact on different QOL domains. This paper brings level 1b evidence 
      which demonstrates the importance of MCID as an adjunct for estimation of QOL in 
      patients undergoing skull base surgery.
FAU - Amit, Moran
AU  - Amit M
AD  - The Department of Otolaryngology Head and Neck Surgery, Sackler Faculty of 
      Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv University, 6 Weizmann St., 
      Tel Aviv, 64239, Israel.
FAU - Abergel, Avraham
AU  - Abergel A
FAU - Fliss, Dan M
AU  - Fliss DM
FAU - Gil, Ziv
AU  - Gil Z
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Curr Oncol Rep
JT  - Current oncology reports
JID - 100888967
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Psychometrics
MH  - *Quality of Life
MH  - Skull Base Neoplasms/*psychology/*surgery
MH  - *Surveys and Questionnaires
EDAT- 2012/01/27 06:00
MHDA- 2012/05/15 06:00
CRDT- 2012/01/27 06:00
PHST- 2012/01/27 06:00 [entrez]
PHST- 2012/01/27 06:00 [pubmed]
PHST- 2012/05/15 06:00 [medline]
AID - 10.1007/s11912-012-0222-3 [doi]
PST - ppublish
SO  - Curr Oncol Rep. 2012 Apr;14(2):175-81. doi: 10.1007/s11912-012-0222-3.