PMID- 22279133
OWN - NLM
STAT- MEDLINE
DCOM- 20120418
LR  - 20230216
IS  - 1541-6100 (Electronic)
IS  - 0022-3166 (Linking)
VI  - 142
IP  - 3
DP  - 2012 Mar
TI  - Stearidonic acid: is there a role in the prevention and management of type 2 
      diabetes mellitus?
PG  - 635S-640S
LID - 10.3945/jn.111.146829 [doi]
AB  - Obesity and its related comorbidities are major public health concerns in the 
      United States with over two-thirds of adults and one-third of children classified 
      as overweight or obese. The prevalence of type 2 diabetes mellitus (T2DM) has 
      similarly risen to an estimated 25.8 million, which accounts for a staggering 
      $174 billion in annual healthcare costs. Identification of dietary interventions 
      that protect against the development of T2DM would markedly reduce the medical 
      and economic consequences of the disease. Hence, we review current evidence 
      supporting a role of (n-3) PUFA in T2DM and explore potential therapeutic 
      implications of stearidonic acid (SDA). The low consumption of fish in the US 
      along with a reduced efficiency to interconvert most plant (n-3) PUFA highlights 
      a need to find alternative sources of (n-3) PUFA. The efficient biological 
      conversion of SDA to EPA underscores the potential implications of SDA as a 
      source of (n-3) PUFA. The full therapeutic efficacy of SDA remains to be further 
      determined. However, recent data have suggested a protective role of SDA 
      consumption on markers of dyslipidemia and inflammation. The AHA recommends that 
      healthy individuals consume oily fish at least twice per week and individuals 
      with a history of cardiovascular disease consume 1 g of EPA+DHA/d. These goals 
      will likely not be met by the typical American diet. Therefore, SDA may represent 
      a sustainable alternative to marine-based (n-3) PUFA and may have novel 
      therapeutic efficacy regarding the development of T2DM.
FAU - Banz, William J
AU  - Banz WJ
AD  - Department of Animal Science, Southern Illinois University, School of Medicine, 
      Carbondale, IL, USA. banz@siu.edu
FAU - Davis, Jeremy E
AU  - Davis JE
FAU - Clough, Richard W
AU  - Clough RW
FAU - Cheatwood, Joseph L
AU  - Cheatwood JL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120125
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Fish Oils)
RN  - 0 (Plant Oils)
RN  - P4CEK3495O (stearidonic acid)
SB  - IM
MH  - Diabetes Mellitus, Type 2/*diet therapy/metabolism/*prevention & control
MH  - Dietary Supplements
MH  - Fatty Acids, Omega-3/*administration & dosage
MH  - Fish Oils/administration & dosage
MH  - Humans
MH  - Nutrition Policy
MH  - Plant Oils/administration & dosage
MH  - United States
EDAT- 2012/01/27 06:00
MHDA- 2012/04/19 06:00
CRDT- 2012/01/27 06:00
PHST- 2012/01/27 06:00 [entrez]
PHST- 2012/01/27 06:00 [pubmed]
PHST- 2012/04/19 06:00 [medline]
AID - S0022-3166(22)02853-X [pii]
AID - 10.3945/jn.111.146829 [doi]
PST - ppublish
SO  - J Nutr. 2012 Mar;142(3):635S-640S. doi: 10.3945/jn.111.146829. Epub 2012 Jan 25.