PMID- 22279475
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1735-7136 (Electronic)
IS  - 1735-1995 (Print)
IS  - 1735-1995 (Linking)
VI  - 16
IP  - 8
DP  - 2011 Aug
TI  - Genetic association of TNF-alpha-308 G/A and -863 C/A polymorphisms with late onset 
      Alzheimer's disease in Azeri Turk population of Iran.
PG  - 1006-13
AB  - BACKGROUND: Recent findings suggest that production of pro-inflammatory 
      cytokines, such as Tumour Necrosis Factor-alpha (TNF-alpha), is increased in the 
      brain tissue of patients suffering late-onset Alzheimer's disease (LOAD) and play 
      an important role in the pathogenesis of this disease. Several epidemiological 
      studies also suggest that patients taking anti-inflammatory drugs have a 
      decreased risk of developing AD. TNF-alpha is an important pro inflammatory cytokine 
      that is unregulated in Alzheimer's patients. Functional polymorphisms in tumor 
      necrosis factor alpha (TNF-alpha) can affect immune response, inflammation, tissue 
      injury and possibly the susceptibility to Alzheimer disease (AD). METHODS: We 
      used the polymorphic DNA markers (-308G/A) and (-863C/A) to study the association 
      of TNF-alpha gene mutations with Late-onset Alzheimer's disease (LOAD) and the 
      relation between clinical features and genotypes in affected individuals. A total 
      of 160 patient samples and 163 healthy controls from west northern Iran (Eastern 
      Azerbaijan) were genotyped for the two polymorphisms by the PCR-RFLP method and 
      genotype frequencies were statistically determined. RESULTS: Our data showed 
      significant difference in TNF-alpha-308 G/A genotype and pro inflammatory cytokine 
      allele frequencies between the Alzheimer disease patients and healthy subjects. 
      Contrary to that, no significant difference was observed in TNF-alpha-863 C/A 
      genotype and allele frequencies between these two groups. CONCLUSIONS: TNF-alpha-308 
      G/A gene polymorphism could affect cerebral inflammatory response and the risk of 
      late-onset Alzheimer disease but -863 C/A polymorphism does not influence the 
      risk of this disease and this possible association between TNF-alpha -308G/A and 
      -863C/A gene polymorphisms have to be further elucidated in larger case control 
      studies.
FAU - Ardebili, Seiied Moitaba Mohaddes
AU  - Ardebili SM
AD  - Associate Professor, Department of Medical Genetics, School of Medicine, Tabriz 
      University of Medical Sciences, Tabriz, Iran.
FAU - Yeghaneh, Tarlan
AU  - Yeghaneh T
FAU - Gharesouran, Jalal
AU  - Gharesouran J
FAU - Rezazadeh, Maryam
AU  - Rezazadeh M
FAU - Farhoudi, Mehdi
AU  - Farhoudi M
FAU - Ayromlou, Hormoz
AU  - Ayromlou H
FAU - Talebi, Mahnaz
AU  - Talebi M
FAU - Ghojazadeh, Morteza
AU  - Ghojazadeh M
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Res Med Sci
JT  - Journal of research in medical sciences : the official journal of Isfahan 
      University of Medical Sciences
JID - 101235599
PMC - PMC3263076
OTO - NOTNLM
OT  - -308G/A
OT  - -863C/A
OT  - Alzheimer
OT  - PCR-RFLP
OT  - Polymorphism
OT  - TNF- alpha
OT  - beta-Amyloid
COIS- Conflict of Interests Authors have no conflict of interests.
EDAT- 2012/01/27 06:00
MHDA- 2012/01/27 06:01
PMCR- 2011/08/01
CRDT- 2012/01/27 06:00
PHST- 2011/03/01 00:00 [received]
PHST- 2011/08/11 00:00 [received]
PHST- 2012/01/27 06:00 [entrez]
PHST- 2012/01/27 06:00 [pubmed]
PHST- 2012/01/27 06:01 [medline]
PHST- 2011/08/01 00:00 [pmc-release]
AID - JRMS-16-1006 [pii]
PST - ppublish
SO  - J Res Med Sci. 2011 Aug;16(8):1006-13.