PMID- 22279954
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20190221
IS  - 0003-4894 (Print)
IS  - 0003-4894 (Linking)
VI  - 120
IP  - 12
DP  - 2011 Dec
TI  - Expression of ABC transporters is an unfavorable prognostic factor in laryngeal 
      squamous cell carcinoma.
PG  - 820-7
AB  - OBJECTIVES: Two prominent and well-characterized representatives of adenosine 
      triphosphate-binding cassette (ABC) transporter - breast cancer resistance 
      protein (BCRP or ABCG2) and P-glycoprotein (P-gp or ABCB1) - are known to be 
      membrane transporters associated with multidrug resistance. The aim of this study 
      was to explore the correlation between ABC transporter expression and the 
      clinicopathologic characteristics, proliferative index, and apoptotic index and 
      their prognostic value in laryngeal squamous cell carcinoma (LSCC). METHODS: 
      Paraffin sections of 98 human LSCC specimens were investigated with 
      immunohistochemical techniques. The relationship between ABCG2 and ABCB1 
      expression and clinicopathologic parameters, proliferative activities, and 
      apoptotic activities and their prognostic value in patients' overall survival 
      rate were subsequently analyzed. RESULTS: Immunohistochemical analysis revealed 
      positive expression of ABCG2 and ABCB1 in 52.0% and 41.8% of patients, 
      respectively. There was a positive correlation between ABCG2 expression and ABCB1 
      expression. The presence of these two proteins was significantly related to 
      clinical stage, lymph node metastasis, and overall survival in LSCC. 
      Interestingly, up-regulation of ABCG2 expression was found to be associated with 
      increased proliferation, but that of ABCB1 was not. Up-regulation of both ABCG2 
      expression and ABCB1 expression was associated with decreased apoptosis. 
      CONCLUSIONS: The results of this study revealed that the presence of ABCG2 and/or 
      ABCB1 is predictive for malignant progression and is an independent prognostic 
      factor in LSCC. The mechanism of ABC transporters may contribute to chemotherapy 
      resistance by promoting proliferation and/or suppressing apoptosis.
FAU - Shen, Bin
AU  - Shen B
AD  - Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiaotong University 
      Affiliated First People's Hospital, Shanghai, China.
FAU - Li, Dawei
AU  - Li D
FAU - Dong, Pin
AU  - Dong P
FAU - Gao, Shang
AU  - Gao S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann Otol Rhinol Laryngol
JT  - The Annals of otology, rhinology, and laryngology
JID - 0407300
RN  - 0 (ABCB1 protein, human)
RN  - 0 (ABCG2 protein, human)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 1)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily G, Member 2)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism
MH  - ATP Binding Cassette Transporter, Subfamily G, Member 2
MH  - ATP-Binding Cassette Transporters/*metabolism
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*metabolism/mortality/pathology
MH  - Disease Progression
MH  - Female
MH  - Head and Neck Neoplasms/*metabolism/mortality/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/*metabolism/mortality/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/metabolism
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Survival Analysis
EDAT- 2012/01/28 06:00
MHDA- 2012/02/10 06:00
CRDT- 2012/01/28 06:00
PHST- 2012/01/28 06:00 [entrez]
PHST- 2012/01/28 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
AID - 10.1177/000348941112001208 [doi]
PST - ppublish
SO  - Ann Otol Rhinol Laryngol. 2011 Dec;120(12):820-7. doi: 
      10.1177/000348941112001208.