PMID- 22281110
OWN - NLM
STAT- MEDLINE
DCOM- 20120814
LR  - 20220311
IS  - 1097-6779 (Electronic)
IS  - 0016-5107 (Linking)
VI  - 75
IP  - 4
DP  - 2012 Apr
TI  - Can rebamipide and proton pump inhibitor combination therapy promote the healing 
      of endoscopic submucosal dissection-induced ulcers? A randomized, prospective, 
      multicenter study.
PG  - 739-47
LID - 10.1016/j.gie.2011.11.004 [doi]
AB  - BACKGROUND: There has been no consensus regarding the optimal treatment durations 
      and drug regimens in patients with endoscopic submucosal dissection (ESD)-induced 
      ulcers. OBJECTIVE: To assess the efficacy of proton pump inhibitor (PPI) and 
      rebamipide combination therapy compared with PPI monotherapy for ESD-induced 
      ulcer healing. DESIGN: Randomized, prospective, controlled study; clinical trial. 
      SETTING: Five hospitals in a University Medical Center group in Korea. PATIENTS: 
      This study involved 290 adults (309 lesions) who underwent ESD for gastric 
      adenoma or early gastric cancer. INTERVENTION: PPI and rebamipide combination 
      therapy. MAIN OUTCOME MEASUREMENTS: The ulcer healing rate at 4 weeks after ESD. 
      RESULTS: The ulcer healing rates at 4 weeks after ESD in the PPI and rebamipide 
      combination therapy group were significantly higher than those in the PPI alone 
      group, both in the full analysis (94.9% vs 89.9%; P < .0001) and in the 
      per-protocol analysis (94.5% vs 91.2%; P = .020). This combination therapy was an 
      independent predictive factor for a high ulcer healing rate (adjusted odds ratio 
      [OR] 5.572; 95% confidence interval [CI], 2.615-11.876; P = .014). Additionally, 
      the combination therapy group exhibited a higher quality of ulcer healing than 
      the PPI monotherapy group (reviewer 1: P = .027; OR 1.949; 95% CI, 1.077-3.527; 
      reviewer 2: P = .027; OR 1.933; 95% CI, 1.074-3.481). LIMITATIONS: Open-label 
      study. CONCLUSION: PPI and rebamipide combination therapy had a superior 4-week 
      ESD-induced ulcer healing rate and quality of ulcer healing compared with PPI 
      monotherapy. ( CLINICAL TRIAL REGISTRATION NUMBER: NCT01167101.).
CI  - Copyright A(c) 2012 American Society for Gastrointestinal Endoscopy. Published by 
      Mosby, Inc. All rights reserved.
FAU - Shin, Woon Geon
AU  - Shin WG
AD  - Department of Internal Medicine, Kangdong Sacred Heart Hospital, Seoul, Korea.
FAU - Kim, Sung Jung
AU  - Kim SJ
FAU - Choi, Min Ho
AU  - Choi MH
FAU - Kim, Kyoung Oh
AU  - Kim KO
FAU - Jang, Hyun Joo
AU  - Jang HJ
FAU - Park, Cheol Hee
AU  - Park CH
FAU - Baek, Il Hyun
AU  - Baek IH
FAU - Kim, Kyung Ho
AU  - Kim KH
FAU - Baik, Gwang Ho
AU  - Baik GH
FAU - Kae, Sea Hyub
AU  - Kae SH
FAU - Kim, Jong Hyeok
AU  - Kim JH
FAU - Kim, Hak Yang
AU  - Kim HY
LA  - eng
SI  - ClinicalTrials.gov/NCT01167101
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120126
PL  - United States
TA  - Gastrointest Endosc
JT  - Gastrointestinal endoscopy
JID - 0010505
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Proton Pump Inhibitors)
RN  - 0 (Quinolones)
RN  - LR583V32ZR (rebamipide)
RN  - OF5P57N2ZX (Alanine)
SB  - IM
MH  - Adenoma/*surgery
MH  - Aged
MH  - Alanine/*analogs & derivatives/therapeutic use
MH  - Anti-Ulcer Agents/*therapeutic use
MH  - Carcinoma/*surgery
MH  - Chi-Square Distribution
MH  - Confidence Intervals
MH  - Dissection/adverse effects
MH  - Drug Therapy, Combination
MH  - Female
MH  - Gastric Mucosa/surgery
MH  - Gastroscopy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Quinolones/*therapeutic use
MH  - Stomach Neoplasms/*surgery
MH  - Stomach Ulcer/*drug therapy/etiology
EDAT- 2012/01/28 06:00
MHDA- 2012/08/15 06:00
CRDT- 2012/01/28 06:00
PHST- 2011/06/17 00:00 [received]
PHST- 2011/11/03 00:00 [accepted]
PHST- 2012/01/28 06:00 [entrez]
PHST- 2012/01/28 06:00 [pubmed]
PHST- 2012/08/15 06:00 [medline]
AID - S0016-5107(11)02393-5 [pii]
AID - 10.1016/j.gie.2011.11.004 [doi]
PST - ppublish
SO  - Gastrointest Endosc. 2012 Apr;75(4):739-47. doi: 10.1016/j.gie.2011.11.004. Epub 
      2012 Jan 26.