PMID- 22281890
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20190507
IS  - 2520-8721 (Electronic)
IS  - 1109-3099 (Linking)
VI  - 10
IP  - 4
DP  - 2011 Oct-Dec
TI  - Parathyroid carcinoma in multiple endocrine neoplasia type 1. Case report and 
      review of the literature.
PG  - 326-31
AB  - Parathyroid carcinoma is an infrequent cause of primary hyperparathyroidism. 
      Although hyperparathyroidism in multiple endocrine neoplasia 1 (MEN1) syndrome is 
      the most common manifestation, parathyroid carcinoma is rare. We report a male 
      patient who was diagnosed at 44 years of age with parathyroid carcinoma in the 
      context of MEN1 syndrome coincident with a malignant gastrinoma and 
      non-functioning adrenal adenomas. A genetic analysis revealed the mutation W183C 
      in exon 3 of the MEN1 gene. The diagnosis of carcinoma was made after parathyroid 
      surgery; there had been no clinical suspicion prior to surgery, as the patient 
      had presented only moderate hypercalcemia. Our review of the few published cases 
      of parathyroid carcinoma in MEN1 syndrome reported in the literature indicates 
      that MEN1 gene mutations do not confer a greater risk for parathyroid carcinoma 
      and do not appear to differ from sporadic parathyroid carcinoma.
FAU - del Pozo, Carlos
AU  - del Pozo C
AD  - Service of Endocrinology, Hospital Universitari Mutua de Terrassa, Terrassa, 
      Barcelona, Spain. 11774cpp@comb.cat
FAU - Garcia-Pascual, Luis
AU  - Garcia-Pascual L
FAU - Balsells, Montserrat
AU  - Balsells M
FAU - Barahona, Maria-Jose
AU  - Barahona MJ
FAU - Veloso, Enrique
AU  - Veloso E
FAU - Gonzalez, Clarisa
AU  - Gonzalez C
FAU - Anglada-Barcelo, Jordi
AU  - Anglada-Barcelo J
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - Hormones (Athens)
JT  - Hormones (Athens, Greece)
JID - 101142469
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Adult
MH  - Carcinoma/*complications/diagnosis/genetics/pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*complications/diagnosis/genetics/pathology
MH  - Parathyroid Neoplasms/*complications/diagnosis/genetics/pathology
MH  - Proto-Oncogene Proteins/genetics
EDAT- 2012/01/28 06:00
MHDA- 2012/05/25 06:00
CRDT- 2012/01/28 06:00
PHST- 2012/01/28 06:00 [entrez]
PHST- 2012/01/28 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
AID - 10.14310/horm.2002.1325 [doi]
PST - ppublish
SO  - Hormones (Athens). 2011 Oct-Dec;10(4):326-31. doi: 10.14310/horm.2002.1325.