PMID- 22282406 OWN - NLM STAT- MEDLINE DCOM- 20120919 LR - 20151119 IS - 1522-2586 (Electronic) IS - 1053-1807 (Linking) VI - 35 IP - 6 DP - 2012 Jun TI - Contrast-enhanced MRI index of diffuse myocardial fibrosis is increased in primary aldosteronism. PG - 1349-55 LID - 10.1002/jmri.23592 [doi] AB - PURPOSE: To assess the degree of myocardial fibrosis in patients with primary aldosteronism (PA). MATERIALS AND METHODS: Twenty-five patients with PA and 12 age-matched healthy volunteers underwent cine and late gadolinium enhancement (LGE) magnetic resonance imaging (MRI) on a 1.5 T MR system. From volume-time curves of cine MRI, the time for deceleration (Tdec) was determined to assess the left ventricle (LV) chamber stiffness. Based on phase-sensitive reconstructed LGE images, a fibrosis index called enhancement value (EV) was computed as the signal intensity change in the myocardium over blood before and after contrast. Both Tdec and EV were compared between patients and controls. The association between Tdec and EV was investigated. RESULTS: Patients showed a significantly higher EV (0.43 +/- 0.05 vs. 0.36 +/- 0.07; P = 0.002) and a significantly shorter Tdec (11.5 +/- 3.5 %RR vs. 15.3 +/- 2.4 %RR; P = 0.004) than controls. Significant correlations between EV and Tdec were observed in patients (r = -0.46, P = 0.018), in controls (r = -0.68, P = 0.015) and in all subjects (r = -0.63, P < 0.001). CONCLUSION: The fibrosis index is increased in patients with PA and the increase imposes an adverse effect on LV diastolic function. CI - Copyright (c) 2012 Wiley Periodicals, Inc. FAU - Su, Mao-Yuan M AU - Su MY AD - Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan. FAU - Wu, Vin-Cent AU - Wu VC FAU - Yu, Hsi-Yu AU - Yu HY FAU - Lin, Yen-Hung AU - Lin YH FAU - Kuo, Chin-Chi AU - Kuo CC FAU - Liu, Kao-Lang AU - Liu KL FAU - Wang, Shuo-Meng AU - Wang SM FAU - Chueh, Shih-Chieh AU - Chueh SC FAU - Lin, Lian-Yu AU - Lin LY FAU - Wu, Kwan-Dun AU - Wu KD FAU - Tseng, Wen-Yih I AU - Tseng WY LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20120126 PL - United States TA - J Magn Reson Imaging JT - Journal of magnetic resonance imaging : JMRI JID - 9105850 RN - 0 (Contrast Media) RN - 84F6U3J2R6 (gadodiamide) RN - K2I13DR72L (Gadolinium DTPA) SB - IM MH - *Algorithms MH - Contrast Media MH - Endomyocardial Fibrosis/*etiology/*pathology MH - Female MH - *Gadolinium DTPA MH - Humans MH - Hyperaldosteronism/*complications/diagnosis/pathology MH - Image Enhancement/methods MH - Image Interpretation, Computer-Assisted/*methods MH - Magnetic Resonance Imaging, Cine/*methods MH - Male MH - Middle Aged MH - Reproducibility of Results MH - Sensitivity and Specificity EDAT- 2012/01/28 06:00 MHDA- 2012/09/20 06:00 CRDT- 2012/01/28 06:00 PHST- 2011/06/14 00:00 [received] PHST- 2011/12/29 00:00 [accepted] PHST- 2012/01/28 06:00 [entrez] PHST- 2012/01/28 06:00 [pubmed] PHST- 2012/09/20 06:00 [medline] AID - 10.1002/jmri.23592 [doi] PST - ppublish SO - J Magn Reson Imaging. 2012 Jun;35(6):1349-55. doi: 10.1002/jmri.23592. Epub 2012 Jan 26.