PMID- 22284243 OWN - NLM STAT- MEDLINE DCOM- 20120626 LR - 20151119 IS - 1879-0828 (Electronic) IS - 0953-6205 (Linking) VI - 23 IP - 2 DP - 2012 Mar TI - The association of physical activity with novel adipokines in patients with type 2 diabetes. PG - 137-42 LID - 10.1016/j.ejim.2011.10.020 [doi] AB - BACKGROUND: Adipose-tissue derivatives, known as adipokines, have been involved in the inflammatory-mediated metabolic and cardiovascular disorders of type 2 diabetes mellitus (T2DM). This study examined the association between novel adipokines and self-reported physical activity, a potential anti-inflammatory mediator. METHODS: We enrolled 247 men and women with T2DM, free from overt cardiovascular disease. Based on a physical activity questionnaire, patients were classified into groups: A) sedentary, who did not report any physical activity or reported light activities<2 h/week and B) active, referring to low or moderate-intensity physical activities>2 h/week. Among them, 88 patients were randomly selected to perform a cardiorespiratory ergocycle testing. Clinical parameters, glycemic and lipid profiles, HOMA-IR, and serum levels of visfatin, apelin, vaspin, ghrelin and adiponectin were assessed. RESULTS: With the exception of fat-mass, our groups did not differ in anthropometric parameters and pharmaceutical regimen. Active patients showed ameliorated glucose regulation, HOMA-IR, hsCRP and exercise capacity compared to sedentary counterparts (p<0.01). Active rather than sedentary patients showed lower visfatin (10.16+/-5.53 ng/ml vs 14.77+/-8.48 ng/ml, p=0.013), higher apelin (1.39+/-0.65 ng/ml vs 1.04+/-0.35 ng/ml, p=0.018) and adiponectin (11.82+/-3.06 mug/ml vs 7.81+/-2.11 mug/ml, p=0.033) levels. There were non-significant differences in the rest of parameters between groups. After adjusting for age, sex and BMI, physical activity along with hsCRP and ghrelin remained independent determinants of visfatin levels (R(2)=0.328, p=0.032), while physical activity was independently associated with apelin (R(2)=0.221, p=0.022). CONCLUSIONS: Self-controlled physical activity of, even, moderate intensity ameliorates adipokines, such as visfatin, apelin and adiponectin, in patients with T2DM. Prospective interventional studies will confirm our results. The ClinicalTrials.gov identifier is: NCT00306176. CI - Copyright (c) 2011 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved. FAU - Kadoglou, Nikolaos P E AU - Kadoglou NP AD - Department of Physical Education and Sports Science at Serres, Aristotle University of Thessaloniki, Greece. nikoskad@yahoo.com FAU - Vrabas, Ioannis S AU - Vrabas IS FAU - Kapelouzou, Alkistis AU - Kapelouzou A FAU - Angelopoulou, Nikoletta AU - Angelopoulou N LA - eng SI - ClinicalTrials.gov/NCT00306176 PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20111129 PL - Netherlands TA - Eur J Intern Med JT - European journal of internal medicine JID - 9003220 RN - 0 (Adipokines) RN - 0 (Biomarkers) RN - 0 (Blood Glucose) SB - IM MH - Adipokines/*blood MH - Adipose Tissue/metabolism MH - Adiposity/*physiology MH - Biomarkers/blood MH - Blood Glucose/metabolism MH - Body Mass Index MH - Cross-Sectional Studies MH - Diabetes Mellitus, Type 2/*blood/physiopathology MH - Disease Progression MH - Enzyme-Linked Immunosorbent Assay MH - Exercise/*physiology MH - Exercise Test MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Middle Aged MH - Motor Activity/*physiology MH - Prognosis MH - Prospective Studies MH - Surveys and Questionnaires EDAT- 2012/01/31 06:00 MHDA- 2012/06/27 06:00 CRDT- 2012/01/31 06:00 PHST- 2011/07/09 00:00 [received] PHST- 2011/10/26 00:00 [revised] PHST- 2011/10/28 00:00 [accepted] PHST- 2012/01/31 06:00 [entrez] PHST- 2012/01/31 06:00 [pubmed] PHST- 2012/06/27 06:00 [medline] AID - S0953-6205(11)00264-0 [pii] AID - 10.1016/j.ejim.2011.10.020 [doi] PST - ppublish SO - Eur J Intern Med. 2012 Mar;23(2):137-42. doi: 10.1016/j.ejim.2011.10.020. Epub 2011 Nov 29.