PMID- 22284244
OWN - NLM
STAT- MEDLINE
DCOM- 20120626
LR  - 20220408
IS  - 1879-0828 (Electronic)
IS  - 0953-6205 (Linking)
VI  - 23
IP  - 2
DP  - 2012 Mar
TI  - Quality of life in type 2 diabetes mellitus after a very low calorie diet and 
      exercise.
PG  - 143-9
LID - 10.1016/j.ejim.2011.07.004 [doi]
AB  - OBJECTIVE: To evaluate whether the addition of exercise to a very low calorie 
      diet (VLCD) has beneficial short- and long-term effects on health-related quality 
      of life (QoL) in obese patients with type 2 diabetes mellitus (T2DM). METHODS: We 
      included 27 obese, insulin-dependent T2DM patients in a 16-week VLCD study, of 
      whom 13 participated simultaneously in an exercise program (VLCD+E). Before, 
      immediately after and 18 months after the intervention anthropometric 
      measurements, glucoregulation and QoL (SF-36, HADS, NHP and MFI-20) were 
      assessed. Patients were compared to healthy lean and obese (matched for body mass 
      index) controls matched for gender and age. RESULTS: At baseline, T2DM patients 
      had significantly worse QoL scores in 18 and 14 of the 22 subscales of the QoL 
      questionnaires, compared to lean and obese controls, resp. The 16-week VLCD 
      (n=27) decreased bodyweight (-25.4+/-1.3 kg, p<0.0001, p=0.179 between groups), and 
      improved glucoregulation (HbA1c -1.3+/-0.3%, p<0.0001, p=0.488 between groups) and 
      9 (VLCD-only) and 11 (VLCD+E) of the 22 subscales of QoL. After 18 months, in the 
      VLCD+E group the QoL subscales did not differ from those in obese controls and 
      only 4 of the 22 subscales were significantly worse compared to lean controls. 
      However, in the VLCD-only group 17 and 13 of the 22 QoL subscales were 
      significantly worse compared to the lean and obese controls, resp. CONCLUSION: A 
      16-week VLCD induces considerable weight loss, metabolic amelioration, and major 
      improvements in QoL in obese T2DM patients. The addition of exercise is of 
      paramount importance for the maintenance of better QoL.
CI  - Copyright (c) 2011 European Federation of Internal Medicine. Published by Elsevier 
      B.V. All rights reserved.
FAU - Snel, Marieke
AU  - Snel M
AD  - Department of Endocrinology and Metabolism/General Internal Medicine, Leiden 
      University Medical Center, Leiden, The Netherlands. M.Snel@lumc.nl
FAU - Sleddering, Maria A
AU  - Sleddering MA
FAU - Vd Peijl, Inge D
AU  - Vd Peijl ID
FAU - Romijn, Johannes A
AU  - Romijn JA
FAU - Pijl, Hanno
AU  - Pijl H
FAU - Meinders, A Edo
AU  - Meinders AE
FAU - Jazet, Ingrid M
AU  - Jazet IM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20110817
PL  - Netherlands
TA  - Eur J Intern Med
JT  - European journal of internal medicine
JID - 9003220
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Blood Glucose/*metabolism
MH  - Body Mass Index
MH  - Caloric Restriction/*methods
MH  - Diabetes Mellitus, Type 2/blood/*psychology/therapy
MH  - Exercise/*physiology
MH  - Exercise Therapy/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Quality of Life
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
MH  - Weight Loss/*physiology
EDAT- 2012/01/31 06:00
MHDA- 2012/06/27 06:00
CRDT- 2012/01/31 06:00
PHST- 2011/02/04 00:00 [received]
PHST- 2011/07/05 00:00 [revised]
PHST- 2011/07/11 00:00 [accepted]
PHST- 2012/01/31 06:00 [entrez]
PHST- 2012/01/31 06:00 [pubmed]
PHST- 2012/06/27 06:00 [medline]
AID - S0953-6205(11)00149-X [pii]
AID - 10.1016/j.ejim.2011.07.004 [doi]
PST - ppublish
SO  - Eur J Intern Med. 2012 Mar;23(2):143-9. doi: 10.1016/j.ejim.2011.07.004. Epub 
      2011 Aug 17.