PMID- 22284319
OWN - NLM
STAT- MEDLINE
DCOM- 20120511
LR  - 20131121
IS  - 1873-4529 (Electronic)
IS  - 0952-8180 (Linking)
VI  - 24
IP  - 1
DP  - 2012 Feb
TI  - Propofol-related infusion syndrome induced by "moderate dosage" in a patient with 
      severe head trauma.
PG  - 51-4
LID - 10.1016/j.jclinane.2011.03.008 [doi]
AB  - Propofol is widely used for sedating critically ill adult patients because of its 
      rapid onset and short recovery times, even after prolonged use. Propofol may be 
      associated with a life-threatening syndrome, propofol-related infusion syndrome 
      (PRIS), which includes cardiac failure, severe metabolic acidosis, renal failure, 
      and rhabodomyolysis. The pathophysiology is incompletely understood. 
      Propofol-related infusion syndrome seems to be dose-related, and it occurs 
      generally in patients undergoing long-term (> 48 hrs) sedation at higher doses (> 
      4 mg/kg/hr). A case of PRIS in a patient after severe head injury is presented.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Annecke, Thorsten
AU  - Annecke T
AD  - Department of Anesthesiology, Ludwig-Maximilians-University Munich, D-80336 
      Munich, Germany. thorsten.annecke@med.uni-muenchen.de
FAU - Conzen, Peter
AU  - Conzen P
FAU - Ney, Ludwig
AU  - Ney L
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Clin Anesth
JT  - Journal of clinical anesthesia
JID - 8812166
RN  - 0 (Anesthetics, Intravenous)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Acidosis/chemically induced
MH  - Adult
MH  - Anesthetics, Intravenous/administration & dosage/*adverse effects
MH  - Craniocerebral Trauma/*physiopathology/therapy
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Heart Failure/chemically induced
MH  - Humans
MH  - Propofol/administration & dosage/*adverse effects
MH  - Renal Insufficiency/chemically induced
MH  - Rhabdomyolysis/chemically induced
MH  - Syndrome
MH  - Trauma Severity Indices
EDAT- 2012/01/31 06:00
MHDA- 2012/05/12 06:00
CRDT- 2012/01/31 06:00
PHST- 2010/03/28 00:00 [received]
PHST- 2011/03/08 00:00 [revised]
PHST- 2011/03/10 00:00 [accepted]
PHST- 2012/01/31 06:00 [entrez]
PHST- 2012/01/31 06:00 [pubmed]
PHST- 2012/05/12 06:00 [medline]
AID - S0952-8180(11)00332-1 [pii]
AID - 10.1016/j.jclinane.2011.03.008 [doi]
PST - ppublish
SO  - J Clin Anesth. 2012 Feb;24(1):51-4. doi: 10.1016/j.jclinane.2011.03.008.