PMID- 22284500
OWN - NLM
STAT- MEDLINE
DCOM- 20120622
LR  - 20151119
IS  - 1873-3573 (Electronic)
IS  - 0039-9140 (Linking)
VI  - 89
DP  - 2012 Jan 30
TI  - Determination of benzimidazole residues in animal tissue samples by combination 
      of magnetic solid-phase extraction with capillary zone electrophoresis.
PG  - 335-41
LID - 10.1016/j.talanta.2011.12.038 [doi]
AB  - Benzimidazole drugs (BZDs) comprise a large number of synthetic anthelmintics, 
      which are widely used in food-producing animals for prophylactic and therapeutic 
      purposes. To protect consumers from the risks related to BZDs residues, a simple, 
      rapid, and efficient method for simultaneous determination of ten BZDs in animal 
      tissues samples was developed. This analytical procedure involved extracting 
      samples with magnetic solid-phase extraction (MSPE) using magnetite/silica/poly 
      (methacrylic acid-co-ethylene glycol dimethacrylate) (Fe(3)O(4)/SiO(2)/poly 
      (MAA-co-EGDMA)) magnetic microspheres, and determination by capillary zone 
      electrophoresis (CZE). To improve the sensitivity of the method, we employed the 
      electrokinetic injection with field-amplified sample stacking technique (FASS). 
      Berbine solution was used as internal standard to minimize the fluctuation of 
      analytical results. Under the optimized extraction conditions, good linearities 
      were obtained for the ten BZDs with the correlation coefficients (R(2)) above 
      0.9920. The limits of detections (LODs) for ten BZDs were 1.05-10.42 ng/g in 
      swine muscle and 1.06-12.61 ng/g in swine liver, respectively. The intra- and 
      inter-day relative standard deviations (RSDs) of the developed method were less 
      than 13.6%. The recoveries of the ten BZDs for the spiked samples ranged from 
      81.1% to 105.4% with RSDs less than 9.3%.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Hu, Xi-Zhou
AU  - Hu XZ
AD  - Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of 
      Education), Department of Chemistry, Wuhan University, Wuhan 430072, China.
FAU - Chen, Ming-Luan
AU  - Chen ML
FAU - Gao, Qiang
AU  - Gao Q
FAU - Yu, Qiong-Wei
AU  - Yu QW
FAU - Feng, Yu-Qi
AU  - Feng YQ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111220
PL  - Netherlands
TA  - Talanta
JT  - Talanta
JID - 2984816R
RN  - 0 (Anthelmintics)
RN  - 0 (Benzimidazoles)
RN  - 0 (Berberine Alkaloids)
RN  - 0 (Ethylene Glycols)
RN  - 0 (Methacrylates)
RN  - 728C74FB5Z (berbine)
RN  - 7631-86-9 (Silicon Dioxide)
RN  - 7BK5G69305 (ethylene dimethacrylate)
SB  - IM
MH  - Animals
MH  - Anthelmintics/*analysis
MH  - Benzimidazoles/*analysis
MH  - Berberine Alkaloids/chemistry
MH  - Drug Residues/analysis
MH  - Electrophoresis, Capillary
MH  - Ethylene Glycols/chemistry
MH  - Flow Injection Analysis
MH  - Limit of Detection
MH  - Liver/*chemistry
MH  - Magnetics
MH  - Meat/*analysis
MH  - Methacrylates/chemistry
MH  - Muscles/*chemistry
MH  - Silicon Dioxide/chemistry
MH  - Solid Phase Extraction
MH  - Swine
EDAT- 2012/01/31 06:00
MHDA- 2012/06/23 06:00
CRDT- 2012/01/31 06:00
PHST- 2011/10/02 00:00 [received]
PHST- 2011/12/13 00:00 [revised]
PHST- 2011/12/14 00:00 [accepted]
PHST- 2012/01/31 06:00 [entrez]
PHST- 2012/01/31 06:00 [pubmed]
PHST- 2012/06/23 06:00 [medline]
AID - S0039-9140(11)01106-4 [pii]
AID - 10.1016/j.talanta.2011.12.038 [doi]
PST - ppublish
SO  - Talanta. 2012 Jan 30;89:335-41. doi: 10.1016/j.talanta.2011.12.038. Epub 2011 Dec 
      20.