PMID- 22284952
OWN - NLM
STAT- MEDLINE
DCOM- 20121129
LR  - 20191210
IS  - 1768-3122 (Electronic)
IS  - 0248-8663 (Linking)
VI  - 33
IP  - 8
DP  - 2012 Aug
TI  - [Adverse effects of proton pump inhibitors: should we worry about long-term 
      exposure?].
PG  - 439-45
LID - 10.1016/j.revmed.2011.12.011 [doi]
AB  - Long-term treatment with proton pump inhibitors (PPI) is becoming more prevalent. 
      Although they are well tolerated in the short term, serious concerns about 
      long-term use have arisen. Recent data suggest that the latter is associated with 
      an increased risk for osteoporotic fracture (especially vertebral), Clostridium 
      difficile infection and rebound acid hypersecretion after treatment 
      discontinuation. Acute interstitial nephritis is rare but may progress to chronic 
      renal failure. An increased risk of community-acquired pneumonia has not been 
      established in the general population and seems limited to the most vulnerable 
      patients. Consistent data are still missing to correctly assess the risk of iron 
      deficiency, vitamin B12 deficiency or hypomagnesaemia and the risk of digestive 
      malignant diseases, despite the pathophysiological basis that exists concerning 
      gastric malignancy. Many drug interactions can occur on long-term treatment, 
      including some that imply the cytochrome P450 enzymes. Finally, the risk-benefit 
      balance for a chronic PPI use in children seems unfavorable in most cases.
CI  - Copyright (c) 2012 Societe nationale francaise de medecine interne (SNFMI). 
      Published by Elsevier SAS. All rights reserved.
FAU - Roulet, L
AU  - Roulet L
AD  - Service de pharmacologie et toxicologie cliniques, hopitaux universitaires de 
      Geneve, rue Gabrielle-Perret-Gentil 4, Geneva, Switzerland. 
      lucien.roulet@gmail.com
FAU - Vernaz, N
AU  - Vernaz N
FAU - Giostra, E
AU  - Giostra E
FAU - Gasche, Y
AU  - Gasche Y
FAU - Desmeules, J
AU  - Desmeules J
LA  - fre
PT  - Evaluation Study
PT  - Journal Article
PT  - Review
TT  - Effets indesirables des inhibiteurs de la pompe a proton : faut-il craindre de 
      les prescrire au long cours ?
DEP - 20120127
PL  - France
TA  - Rev Med Interne
JT  - La Revue de medecine interne
JID - 8101383
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
CIN - Rev Med Interne. 2012 Aug;33(8):417-20. PMID: 22503239
MH  - Adenocarcinoma/chemically induced/epidemiology
MH  - Anti-Ulcer Agents/administration & dosage/adverse effects/therapeutic use
MH  - Drug Interactions
MH  - Gastrointestinal Neoplasms/chemically induced/epidemiology
MH  - Humans
MH  - Infections/chemically induced/epidemiology
MH  - Nephritis/chemically induced/epidemiology
MH  - Proton Pump Inhibitors/administration & dosage/*adverse effects/therapeutic use
MH  - Risk Assessment
MH  - Time Factors
MH  - Vitamin B 12 Deficiency/chemically induced/epidemiology
EDAT- 2012/01/31 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/01/31 06:00
PHST- 2011/08/30 00:00 [received]
PHST- 2011/12/11 00:00 [revised]
PHST- 2011/12/21 00:00 [accepted]
PHST- 2012/01/31 06:00 [entrez]
PHST- 2012/01/31 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S0248-8663(11)01284-7 [pii]
AID - 10.1016/j.revmed.2011.12.011 [doi]
PST - ppublish
SO  - Rev Med Interne. 2012 Aug;33(8):439-45. doi: 10.1016/j.revmed.2011.12.011. Epub 
      2012 Jan 27.