PMID- 22285019
OWN - NLM
STAT- MEDLINE
DCOM- 20120326
LR  - 20220409
IS  - 2210-7762 (Print)
VI  - 204
IP  - 12
DP  - 2011 Dec
TI  - Molecular cytogenetic characterization of epithelioid hemangioendothelioma.
PG  - 671-6
LID - 10.1016/j.cancergen.2011.11.007 [doi]
AB  - Epithelioid hemangioendothelioma (EHE) is a rare vascular tumor whose 
      pathological diagnosis can be difficult. In the literature two cases of EHE were 
      found to harbor a balanced t(1;3)(p36.3;q25) translocation, suggesting a 
      characteristic chromosomal rearrangement as cause for the development of EHE. In 
      this study, 14 cases of EHE were investigated by interphase fluorescence in situ 
      hybridization (FISH) directed against the translocation breakpoint 1p36.3. A 
      subset of cases was also analyzed by comparative genomic hybridization (CGH) and 
      image cytometry. Five out of eight cases that could be successfully analyzed by 
      FISH harbored a chromosomal break in the 1p36.3 region. The break-apart signals 
      were present in diploid nuclei, and less frequently also in tetraploid nuclei. In 
      the latter, the chromosomal break was present twice, suggesting that polyploidy 
      occurred after the chromosomal alteration. DNA cytometry confirmed that 
      tetraploid cells were present in most examined cases with one case indicating 
      almost equal amounts of diploid and tetraploid tumor cells. CGH revealed single 
      chromosomal imbalances of unclear significance. We could confirm that EHE may 
      harbor a recurrent mutation involving the 1p36.3 chromosomal region thus 
      supporting the notion that the t(1;3)(p36.3;q25) translocation is a relevant 
      genetic finding in this tumor entity.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Woelfel, Cornelius
AU  - Woelfel C
AD  - Institute of Pathology, Jena University Hospital, Jena, Germany.
FAU - Liehr, Thomas
AU  - Liehr T
FAU - Weise, Anja
AU  - Weise A
FAU - Langrehr, Jan
AU  - Langrehr J
FAU - Kotb, Waleed Amin
AU  - Kotb WA
FAU - Pacyna-Gengelbach, Manuela
AU  - Pacyna-Gengelbach M
FAU - Katenkamp, Detlef
AU  - Katenkamp D
FAU - Petersen, Iver
AU  - Petersen I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet
JT  - Cancer genetics
JID - 101539150
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chromosomes, Human, Pair 1
MH  - Chromosomes, Human, Pair 3
MH  - Comparative Genomic Hybridization
MH  - Female
MH  - Hemangioendothelioma, Epithelioid/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Tetraploidy
MH  - *Translocation, Genetic
EDAT- 2012/01/31 06:00
MHDA- 2012/03/27 06:00
CRDT- 2012/01/31 06:00
PHST- 2011/05/10 00:00 [received]
PHST- 2011/09/20 00:00 [revised]
PHST- 2011/11/28 00:00 [accepted]
PHST- 2012/01/31 06:00 [entrez]
PHST- 2012/01/31 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
AID - S2210-7762(11)00341-3 [pii]
AID - 10.1016/j.cancergen.2011.11.007 [doi]
PST - ppublish
SO  - Cancer Genet. 2011 Dec;204(12):671-6. doi: 10.1016/j.cancergen.2011.11.007.