PMID- 22285112
OWN - NLM
STAT- MEDLINE
DCOM- 20120615
LR  - 20120302
IS  - 1532-2653 (Electronic)
IS  - 0967-5868 (Linking)
VI  - 19
IP  - 4
DP  - 2012 Apr
TI  - Distribution of HLA-DQB1 alleles in patients with Kleine-Levin syndrome.
PG  - 628-30
LID - 10.1016/j.jocn.2011.08.020 [doi]
AB  - Kleine-Levin syndrome (KLS) is a rare disorder characterized by recurrent 
      episodes of hypersomnia, cognitive or behavior disturbances, compulsive eating 
      behavior, and hypersexuality. The etiology of KLS remains unknown even though its 
      clinical symptoms suggest an underlying autoimmune process. In this study, we 
      analyzed the human leukocyte antigen (HLA) typing alleles in Taiwanese patients 
      with KLS using the polymerase chain reaction sequence-specific priming technique. 
      We report that an immunoresponsive HLA-DQB1, DQB1 *0602, was detected in 
      significant quantities in patients with KLS (three of 12, p=0.046) and could 
      elevate the risk of KLS (odds ratio, 1.143; 95% confidence interval, 
      0.0982-1.329). In conclusion, an identification of genomic susceptibility to KLS 
      will be helpful in determining the immunospecific targeted therapies for patients 
      with KLS.
CI  - Copyright A(c) 2011 Elsevier Ltd. All rights reserved.
FAU - Huang, Chi-Jung
AU  - Huang CJ
AD  - Department of Medical Research, Cathay General Hospital, Taipei, Taiwan.
FAU - Liao, Hung-Tsai
AU  - Liao HT
FAU - Yeh, Geng-Chang
AU  - Yeh GC
FAU - Hung, Kun-Long
AU  - Hung KL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120130
PL  - Scotland
TA  - J Clin Neurosci
JT  - Journal of clinical neuroscience : official journal of the Neurosurgical Society 
      of Australasia
JID - 9433352
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
SB  - IM
MH  - Adolescent
MH  - Alleles
MH  - Child
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - HLA-DQ beta-Chains/*genetics
MH  - Humans
MH  - Kleine-Levin Syndrome/*genetics
MH  - Male
MH  - Polymerase Chain Reaction
MH  - Taiwan
MH  - Young Adult
EDAT- 2012/01/31 06:00
MHDA- 2012/06/16 06:00
CRDT- 2012/01/31 06:00
PHST- 2011/08/18 00:00 [received]
PHST- 2011/08/23 00:00 [accepted]
PHST- 2012/01/31 06:00 [entrez]
PHST- 2012/01/31 06:00 [pubmed]
PHST- 2012/06/16 06:00 [medline]
AID - S0967-5868(11)00597-2 [pii]
AID - 10.1016/j.jocn.2011.08.020 [doi]
PST - ppublish
SO  - J Clin Neurosci. 2012 Apr;19(4):628-30. doi: 10.1016/j.jocn.2011.08.020. Epub 
      2012 Jan 30.