PMID- 22285292
OWN - NLM
STAT- MEDLINE
DCOM- 20120710
LR  - 20161125
IS  - 1872-6216 (Electronic)
IS  - 0047-6374 (Linking)
VI  - 133
IP  - 2-3
DP  - 2012 Feb-Mar
TI  - Effects of aging and caloric restriction on brainstem satiety center signals in 
      rats.
PG  - 83-91
LID - 10.1016/j.mad.2012.01.004 [doi]
AB  - Age-related increases of body weight and adiposity, indicating dysregulation of 
      food intake/energy expenditure, can be prevented in rodents by long-term 40% 
      caloric restriction. The dorsal vagal complex (DVC), the brainstem center 
      mediating the satiety reflex, has recently emerged as a determinant effector of 
      long-term feeding adaptation. To study the effects of aging and caloric 
      restriction on satiety circuits, leptin and brain-derived neurotrophic factor 
      (BDNF) signaling systems were studied in 2- and 19-month-old ad libitum-fed (AL) 
      and 19-month-old calorie-restricted (CR) rats. Age-induced hyperleptinemia in AL 
      rats was correlated with elevated DVC BDNF immunoreactive concentrations and 
      satiety threshold stability, suggesting functional desensitization of the DVC to 
      these signals. To better understand this phenomenon, mRNA levels of receptor and 
      post-receptor signaling effectors were measured by real-time RT-PCR. Aging 
      selectively increased BDNF receptors and suppressor of cytokine signaling-3 
      (SOCS-3) mRNA levels. Caloric restriction prevented age-related increases of 
      serum leptin, DVC BDNF and SOCS-3 mRNA levels, but not those of BDNF receptors. 
      In CR rats, prevention of leptin resistance-promoting SOCS-3 induction was also 
      observed at the protein level. This study suggests that leptin post-receptor 
      targets and BDNF signaling play a role in the establishment of age-related DVC 
      dysfunction.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Moyse, Emmanuel
AU  - Moyse E
AD  - Laboratory of Neuroendocrinology of Aging, Centre de recherche du Centre 
      hospitalier de l'Universite de Montreal (CRCHUM), Angus Technopole, Montreal, QC, 
      Canada H1W 4A4. emmanuel.moyse@univ-tours.fr
FAU - Bedard, Karine
AU  - Bedard K
FAU - Segura, Stephanie
AU  - Segura S
FAU - Mahaut, Stephanie
AU  - Mahaut S
FAU - Tardivel, Catherine
AU  - Tardivel C
FAU - Ferland, Guylaine
AU  - Ferland G
FAU - Lebrun, Bruno
AU  - Lebrun B
FAU - Gaudreau, Pierrette
AU  - Gaudreau P
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120124
PL  - Ireland
TA  - Mech Ageing Dev
JT  - Mechanisms of ageing and development
JID - 0347227
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Leptin)
RN  - 0 (RNA, Messenger)
RN  - 0 (Socs2 protein, rat)
RN  - 0 (Socs3 protein, rat)
RN  - 0 (Suppressor of Cytokine Signaling 3 Protein)
RN  - 0 (Suppressor of Cytokine Signaling Proteins)
SB  - IM
MH  - Adiposity
MH  - Age Factors
MH  - *Aging
MH  - Animals
MH  - Body Weight
MH  - Brain Stem/*physiology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Caloric Restriction
MH  - Eating/*physiology
MH  - Gene Expression Regulation
MH  - Leptin/metabolism
MH  - Male
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Signal Transduction
MH  - Suppressor of Cytokine Signaling 3 Protein
MH  - Suppressor of Cytokine Signaling Proteins/metabolism
EDAT- 2012/01/31 06:00
MHDA- 2012/07/11 06:00
CRDT- 2012/01/31 06:00
PHST- 2011/02/16 00:00 [received]
PHST- 2011/12/31 00:00 [revised]
PHST- 2012/01/13 00:00 [accepted]
PHST- 2012/01/31 06:00 [entrez]
PHST- 2012/01/31 06:00 [pubmed]
PHST- 2012/07/11 06:00 [medline]
AID - S0047-6374(12)00006-1 [pii]
AID - 10.1016/j.mad.2012.01.004 [doi]
PST - ppublish
SO  - Mech Ageing Dev. 2012 Feb-Mar;133(2-3):83-91. doi: 10.1016/j.mad.2012.01.004. 
      Epub 2012 Jan 24.