PMID- 22286650
OWN - NLM
STAT- MEDLINE
DCOM- 20120529
LR  - 20220330
IS  - 1809-4570 (Electronic)
IS  - 0482-5004 (Linking)
VI  - 52
IP  - 1
DP  - 2012 Jan-Feb
TI  - Leukopenia and thrombocytopenia induced by etanercept: two case reports and 
      literature review.
PG  - 110-2
LID - S0482-50042012000100011 [pii]
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine, and its 
      excess can lead to severe consequences. Those effects are known to be antagonized 
      by TNF-alpha inhibitors. Etanercept is a fusion protein that inhibits TNF-alpha 
      action. As TNF-alpha regulation is related to cellular differentiation of various 
      cellular types involved in immune response through expression of several other 
      cytokines, it is possible that the use of its inhibitors may cause cytopenia. We 
      report two cases of bicytopenia induced by etanercept. Both cases recovered after 
      drug withdrawal. We discuss the need of introduction of routine laboratorial 
      tests in patients using anti-TNF therapy, in order to identify possible 
      hematological changes.
FAU - Azevedo, Valderilio Feijo
AU  - Azevedo VF
AD  - Universidade Federal do Parana - UFPR. valderilio@hotmail.com
FAU - Silva, Marilia Barreto Gameiro
AU  - Silva MB
FAU - Marinello, Debora Karine
AU  - Marinello DK
FAU - Santos, Felipe Dunin Dos
AU  - Santos FD
FAU - Silva, Guilherme Barreto Gameiro
AU  - Silva GB
LA  - eng
LA  - por
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - Brazil
TA  - Rev Bras Reumatol
JT  - Revista brasileira de reumatologia
JID - 0404256
RN  - 0 (Antirheumatic Agents)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - OP401G7OJC (Etanercept)
SB  - IM
MH  - Adult
MH  - Antirheumatic Agents/*adverse effects
MH  - Etanercept
MH  - Female
MH  - Humans
MH  - Immunoglobulin G/*adverse effects
MH  - Leukopenia/*chemically induced
MH  - Male
MH  - Middle Aged
MH  - Receptors, Tumor Necrosis Factor
MH  - Thrombocytopenia/*chemically induced
EDAT- 2012/01/31 06:00
MHDA- 2012/05/30 06:00
CRDT- 2012/01/31 06:00
PHST- 2010/09/04 00:00 [received]
PHST- 2011/11/02 00:00 [accepted]
PHST- 2012/01/31 06:00 [entrez]
PHST- 2012/01/31 06:00 [pubmed]
PHST- 2012/05/30 06:00 [medline]
AID - S0482-50042012000100011 [pii]
PST - ppublish
SO  - Rev Bras Reumatol. 2012 Jan-Feb;52(1):110-2.