PMID- 22287437
OWN - NLM
STAT- MEDLINE
DCOM- 20120518
LR  - 20160511
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Linking)
VI  - 1
IP  - 4
DP  - 2011 Jul-Aug
TI  - What is the origin of Staphylococcus aureus in the early postoperative sinonasal 
      cavity?
PG  - 308-12
LID - 10.1002/alr.20050 [doi]
AB  - BACKGROUND: Despite increasing evidence of a role for Staphylococcus aureus (S. 
      aureus) biofilms in chronic rhinosinusitis (CRS), the origin of this organism in 
      the postsurgical sinonasal cavity had been unclear. Recently, we suggested that 
      the increased culture rate of S. aureus following endoscopic sinus surgery (ESS) 
      may be related to biofilm activity. This study, therefore, was designed to 
      evaluate the origin of early postoperative sinonasal S. aureus and assess the 
      early postoperative outcomes in patients culture-positive for this organism. 
      METHODS: Twenty-nine patients undergoing ESS for medically-recalcitrant CRS were 
      prospectively enrolled. A comprehensive intraoperative S. aureus screening 
      protocol was followed for all patients (including swabs for culture and tissue 
      for fluorescence in situ hybridization [FISH] S. aureus biofilm analysis); early 
      postoperative management included endoscopically-guided swabs for culture in all 
      patients. RESULTS: Twenty of 29 (69.0%) patients cultured S. aureus 
      postoperatively, of which 17 of 20 (85.0%) were screen-positive at surgery. Seven 
      of 11 (63.6%) intraoperatively biofilm-positive but culture-negative patients 
      progressed to culture S. aureus post-ESS. S. aureus culture was associated with 
      selected poorer early post-ESS outcomes. CONCLUSION: S. aureus persists in the 
      sinonasal cavity despite ESS. The postoperative culture of sinonasal S. aureus in 
      patients previously biofilm-positive but culture-negative may reflect the dynamic 
      ability of S. aureus to adapt to the surgically-altered microenvironment with 
      subsequent biofilm dispersal and release of planktonic clones.
CI  - Copyright (c) 2011 American Rhinologic Society-American Academy of Otolaryngic 
      Allergy, LLC.
FAU - Jervis-Bardy, Joshua
AU  - Jervis-Bardy J
AD  - Department of Surgery-Otorhinolaryngology, Head and Neck Surgery, University of 
      Adelaide and Flinders University, Adelaide, Australia.
FAU - Foreman, Andrew
AU  - Foreman A
FAU - Boase, Samuel
AU  - Boase S
FAU - Valentine, Rowan
AU  - Valentine R
FAU - Wormald, Peter-John
AU  - Wormald PJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110428
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
SB  - IM
MH  - *Biofilms
MH  - Chronic Disease
MH  - Endoscopy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Paranasal Sinuses/*microbiology
MH  - Postoperative Complications/*microbiology
MH  - Prognosis
MH  - Prospective Studies
MH  - Rhinitis/*microbiology/surgery
MH  - Sinusitis/*microbiology/surgery
MH  - Staphylococcal Infections/*etiology
MH  - Staphylococcus aureus/isolation & purification
EDAT- 2012/01/31 06:00
MHDA- 2012/05/19 06:00
CRDT- 2012/01/31 06:00
PHST- 2010/08/30 00:00 [received]
PHST- 2010/12/09 00:00 [revised]
PHST- 2011/01/04 00:00 [accepted]
PHST- 2012/01/31 06:00 [entrez]
PHST- 2012/01/31 06:00 [pubmed]
PHST- 2012/05/19 06:00 [medline]
AID - 10.1002/alr.20050 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2011 Jul-Aug;1(4):308-12. doi: 10.1002/alr.20050. Epub 
      2011 Apr 28.