PMID- 22287635
OWN - NLM
STAT- MEDLINE
DCOM- 20120730
LR  - 20211203
IS  - 1362-4962 (Electronic)
IS  - 0305-1048 (Print)
IS  - 0305-1048 (Linking)
VI  - 40
IP  - 10
DP  - 2012 May
TI  - Transcriptional regulation of gene expression during osmotic stress responses by 
      the mammalian target of rapamycin.
PG  - 4368-84
LID - 10.1093/nar/gks038 [doi]
AB  - Although stress can suppress growth and proliferation, cells can induce adaptive 
      responses that allow them to maintain these functions under stress. While 
      numerous studies have focused on the inhibitory effects of stress on cell growth, 
      less is known on how growth-promoting pathways influence stress responses. We 
      have approached this question by analyzing the effect of mammalian target of 
      rapamycin (mTOR), a central growth controller, on the osmotic stress response. 
      Our results showed that mammalian cells exposed to moderate hypertonicity 
      maintained active mTOR, which was required to sustain their cell size and 
      proliferative capacity. Moreover, mTOR regulated the induction of diverse 
      osmostress response genes, including targets of the tonicity-responsive 
      transcription factor NFAT5 as well as NFAT5-independent genes. Genes sensitive to 
      mTOR-included regulators of stress responses, growth and proliferation. Among 
      them, we identified REDD1 and REDD2, which had been previously characterized as 
      mTOR inhibitors in other stress contexts. We observed that mTOR facilitated 
      transcription-permissive conditions for several osmoresponsive genes by enhancing 
      histone H4 acetylation and the recruitment of RNA polymerase II. Altogether, 
      these results reveal a previously unappreciated role of mTOR in regulating 
      transcriptional mechanisms that control gene expression during cellular stress 
      responses.
FAU - Ortells, M Carmen
AU  - Ortells MC
AD  - Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 
      Barcelona, Spain.
FAU - Morancho, Beatriz
AU  - Morancho B
FAU - Drews-Elger, Katherine
AU  - Drews-Elger K
FAU - Viollet, Benoit
AU  - Viollet B
FAU - Laderoute, Keith R
AU  - Laderoute KR
FAU - Lopez-Rodriguez, Cristina
AU  - Lopez-Rodriguez C
FAU - Aramburu, Jose
AU  - Aramburu J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120128
PL  - England
TA  - Nucleic Acids Res
JT  - Nucleic acids research
JID - 0411011
RN  - 0 (Chromatin)
RN  - 0 (Ddit4 protein, mouse)
RN  - 0 (NFATC Transcription Factors)
RN  - 0 (Transcription Factors)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 2.7.7.6 (DNA-Directed RNA Polymerases)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Chromatin/chemistry
MH  - DNA-Directed RNA Polymerases/metabolism
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Mice
MH  - NFATC Transcription Factors/metabolism
MH  - Osmotic Pressure
MH  - Stress, Physiological/*genetics
MH  - TOR Serine-Threonine Kinases/*metabolism
MH  - Transcription Factors/biosynthesis/genetics
MH  - *Transcription, Genetic
PMC - PMC3378878
EDAT- 2012/01/31 06:00
MHDA- 2012/07/31 06:00
PMCR- 2012/01/28
CRDT- 2012/01/31 06:00
PHST- 2012/01/31 06:00 [entrez]
PHST- 2012/01/31 06:00 [pubmed]
PHST- 2012/07/31 06:00 [medline]
PHST- 2012/01/28 00:00 [pmc-release]
AID - gks038 [pii]
AID - 10.1093/nar/gks038 [doi]
PST - ppublish
SO  - Nucleic Acids Res. 2012 May;40(10):4368-84. doi: 10.1093/nar/gks038. Epub 2012 
      Jan 28.