PMID- 22289536
OWN - NLM
STAT- MEDLINE
DCOM- 20120522
LR  - 20220409
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Linking)
VI  - 39
IP  - 6
DP  - 2011
TI  - Predictive capabilities of serum eosinophil cationic protein, percentage of 
      eosinophils and total immunoglobulin E in allergic rhinitis without bronchial 
      asthma.
PG  - 2209-16
AB  - This study identified cut-off values for allergy markers for use in the diagnosis 
      of allergic rhinitis in the absence of other allergic diseases. Total 
      immunoglobulin E (IgE), eosinophil cationic protein (ECP) and the numbers of 
      eosinophils were measured in serum samples from 442 patients with typical 
      symptoms of allergic rhinitis. A definite diagnosis was made on the basis of the 
      presence of specific IgE levels. Cut-off values with a maximal discrimination to 
      diagnose allergic rhinitis were found to be 98.7 IU/ml, 24.7 mug/ml and 4.0% for 
      total IgE, ECP and eosinophils, respectively. Sensitivity, specificity and odds 
      ratio for these values were 75.2%, 69.7% and 6.93, respectively, for total IgE, 
      55.7%, 74.4% and 3.70 for ECP, and 57.5%, 72.0% and 3.47 for eosinophils. A 
      composite score representing positive results for all three markers had a 
      positive predictive value of 85.3%, with an odds ratio of 8.55. It was concluded 
      that total serum IgE, ECP and eosinophil percentage are strong predictors of 
      allergic rhinitis and the determination of cut-off values for these markers can 
      aid in the diagnosis of allergic rhinitis in the clinical setting.
FAU - Jung, Y G
AU  - Jung YG
AD  - Department of Otorhinolaryngology - Head and Neck Surgery, Sungkyunkwan 
      University School of Medicine, Samsung Changwon Hospital, Changwon, Republic of 
      Korea.
FAU - Kim, K H
AU  - Kim KH
FAU - Kim, H Y
AU  - Kim HY
FAU - Dhong, H J
AU  - Dhong HJ
FAU - Chung, S K
AU  - Chung SK
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
RN  - 0 (Biomarkers)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.1.27.- (Eosinophil Cationic Protein)
SB  - IM
MH  - Adolescent
MH  - Aged
MH  - Area Under Curve
MH  - Asthma/*complications/*diagnosis/immunology
MH  - Biomarkers/blood
MH  - Child
MH  - Demography
MH  - *Eosinophil Cationic Protein/blood
MH  - Eosinophils/*immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Middle Aged
MH  - ROC Curve
MH  - Rhinitis, Allergic, Seasonal/*complications/*diagnosis/immunology
MH  - Young Adult
EDAT- 2012/02/01 06:00
MHDA- 2012/05/23 06:00
CRDT- 2012/02/01 06:00
PHST- 2012/02/01 06:00 [entrez]
PHST- 2012/02/01 06:00 [pubmed]
PHST- 2012/05/23 06:00 [medline]
AID - 10.1177/147323001103900617 [doi]
PST - ppublish
SO  - J Int Med Res. 2011;39(6):2209-16. doi: 10.1177/147323001103900617.