PMID- 22289726 OWN - NLM STAT- MEDLINE DCOM- 20120404 LR - 20220419 IS - 1534-4436 (Electronic) IS - 1081-1206 (Linking) VI - 108 IP - 2 DP - 2012 Feb TI - Multiple drug intolerance syndrome: prevalence, clinical characteristics, and management. PG - 88-93 LID - 10.1016/j.anai.2011.11.006 [doi] AB - BACKGROUND: Population-based data on the demographics and clinical characteristics of patients with multiple unrelated drug class intolerances noted in their medical records are lacking. OBJECTIVES: To provide population-based drug "allergy" incidence rates and prevalence, and to identify individuals with multiple drug intolerance syndrome (MDIS) defined by 3 or more unrelated drug class "allergies," and to provide demographic and clinical information on MDIS cases. METHODS: Electronic medical record data from 2,375,424 Kaiser Permanente Southern California health plan members who had a health care visit and at least 11 months of health care coverage during 2009 were reviewed. Population-based drug "allergy" incidence rates and prevalence were determined for 23 unrelated medication classes. RESULTS: On January 1, 2009, 478,283 (20.1%) health plan members had at least one reported "allergy." Individuals with a history of at least 1 "allergy" and females, in general, reported higher population-based new "allergy" incidence rates. Multiple drug intolerance syndrome was present in 49,582 (2.1%). The MDIS cases were significantly older, 62.4 +/- 16.1 years; heavier, body mass index 29.3 +/- 7.1; and likely to be female, 84.9%, compared with average health plan members. They had high rates of health care utilization, medication usage, and new drug "allergy" incidence. They sought medical attention for common nonmorbid conditions. CONCLUSIONS: Multiple drug intolerance syndrome is in part iatrogenic. It is associated with overweight elderly women who have high rates of health care and medication usage. Urticarial syndromes only explain a small fraction of MDIS cases. Multiple drug intolerance syndrome is associated with anxiety, but not predominately with immunoglobulin E (IgE)-mediated allergy or life-threatening illness. Multiple drug intolerance syndrome can be managed by medication avoidance and judicious rechallenge. CI - Copyright (c) 2012 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved. FAU - Macy, Eric AU - Macy E AD - Southern California Permanente Medical Group, Department of Allergy, San Diego Medical Center, San Diego, California, USA. eric.m.macy@kp.org FAU - Ho, Ngoc J AU - Ho NJ LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20111209 PL - United States TA - Ann Allergy Asthma Immunol JT - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JID - 9503580 RN - 0 (Angiotensin-Converting Enzyme Inhibitors) RN - 0 (Narcotics) RN - 0 (Penicillins) SB - IM MH - Adult MH - Age Factors MH - Aged MH - Angiotensin-Converting Enzyme Inhibitors/adverse effects/classification MH - California/epidemiology MH - Drug Hypersensitivity/*diagnosis/drug therapy/*epidemiology MH - Electronic Health Records MH - Female MH - Humans MH - Incidence MH - Male MH - Middle Aged MH - Narcotics/adverse effects/classification MH - Penicillins/adverse effects/classification MH - Prepaid Health Plans/*statistics & numerical data MH - Prevalence MH - Risk Factors MH - Sex Factors MH - Syndrome EDAT- 2012/02/01 06:00 MHDA- 2012/04/05 06:00 CRDT- 2012/02/01 06:00 PHST- 2011/09/22 00:00 [received] PHST- 2011/11/07 00:00 [revised] PHST- 2011/11/20 00:00 [accepted] PHST- 2012/02/01 06:00 [entrez] PHST- 2012/02/01 06:00 [pubmed] PHST- 2012/04/05 06:00 [medline] AID - S1081-1206(11)00901-X [pii] AID - 10.1016/j.anai.2011.11.006 [doi] PST - ppublish SO - Ann Allergy Asthma Immunol. 2012 Feb;108(2):88-93. doi: 10.1016/j.anai.2011.11.006. Epub 2011 Dec 9.