PMID- 22290875
OWN - NLM
STAT- MEDLINE
DCOM- 20120410
LR  - 20211021
IS  - 1520-6300 (Electronic)
IS  - 1042-0533 (Print)
IS  - 1042-0533 (Linking)
VI  - 24
IP  - 2
DP  - 2012 Mar-Apr
TI  - The caloric restriction paradigm: implications for healthy human aging.
PG  - 101-6
LID - 10.1002/ajhb.22243 [doi]
AB  - Underlying the importance of research on the biology of aging is the fact that 
      many nations face the demographic reality of a rapidly aging populace and the 
      looming healthcare challenges that it brings. This reality is a result of aging 
      itself being the most significant risk factor for a range of the most prevalent 
      diseases, including many cancers, cardiovascular disease, and diabetes. 
      Accordingly, interventions are sorely needed that would be able to delay or 
      prevent diseases and disorders associated with the aging process and thereby 
      increase the period of time that aging individuals are in good health (the 
      health-span). Caloric restriction (CR) has emerged as a model of major interest 
      as it is widely agreed that CR is the most potent environmental intervention that 
      delays the onset of aging and extends life span in diverse experimental 
      organisms. A better understanding of the mechanisms by which CR delays aging will 
      reveal new insights into the aging process and the underlying causes of disease 
      vulnerability with age. These novel insights will allow the development of novel 
      treatments and preventive measures for age-associated diseases and disorders.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Anderson, Rozalyn M
AU  - Anderson RM
AD  - Department of Medicine, School of Medicine and Public Health, University of 
      Wisconsin-Madison, Madison, Wisconsin, USA. rmanderson@medicine.wisc.edu
FAU - Weindruch, Richard
AU  - Weindruch R
LA  - eng
GR  - P51 RR000167/RR/NCRR NIH HHS/United States
GR  - P01AG11915/AG/NIA NIH HHS/United States
GR  - R01 AG037000/AG/NIA NIH HHS/United States
GR  - UL1 RR025011/RR/NCRR NIH HHS/United States
GR  - P01 AG011915/AG/NIA NIH HHS/United States
GR  - UL1RR025011/RR/NCRR NIH HHS/United States
GR  - R01 AG040178/AG/NIA NIH HHS/United States
GR  - R01AG037000/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20120130
PL  - United States
TA  - Am J Hum Biol
JT  - American journal of human biology : the official journal of the Human Biology 
      Council
JID - 8915029
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - *Caloric Restriction
MH  - *Energy Intake
MH  - Humans
MH  - Longevity/*physiology
PMC - PMC3705772
MID - NIHMS486834
EDAT- 2012/02/01 06:00
MHDA- 2012/04/11 06:00
PMCR- 2013/07/09
CRDT- 2012/02/01 06:00
PHST- 2011/12/03 00:00 [received]
PHST- 2011/12/26 00:00 [revised]
PHST- 2011/12/27 00:00 [accepted]
PHST- 2012/02/01 06:00 [entrez]
PHST- 2012/02/01 06:00 [pubmed]
PHST- 2012/04/11 06:00 [medline]
PHST- 2013/07/09 00:00 [pmc-release]
AID - 10.1002/ajhb.22243 [doi]
PST - ppublish
SO  - Am J Hum Biol. 2012 Mar-Apr;24(2):101-6. doi: 10.1002/ajhb.22243. Epub 2012 Jan 
      30.