PMID- 22291614
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20230429
IS  - 1662-453X (Electronic)
IS  - 1662-4548 (Print)
IS  - 1662-453X (Linking)
VI  - 6
DP  - 2012
TI  - Molecular Coevolution of Neuropeptides Gonadotropin-Releasing Hormone and 
      Kisspeptin with their Cognate G Protein-Coupled Receptors.
PG  - 3
LID - 10.3389/fnins.2012.00003 [doi]
LID - 3
AB  - The neuropeptides gonadotropin-releasing hormone (GnRH) and kisspeptin (KiSS), 
      and their receptors gonadotropin-releasing hormone receptor (GnRHR) and 
      kisspeptin receptor (KiSSR) play key roles in vertebrate reproduction. Multiple 
      paralogous isoforms of these genes have been identified in various vertebrate 
      species. Two rounds of genome duplication in early vertebrates likely contributed 
      to the generation of these paralogous genes. Genome synteny and phylogenetic 
      analyses in a variety of vertebrate species have provided insights into the 
      evolutionary origin of and relationship between paralogous genes. The paralogous 
      forms of these neuropeptides and their receptors have coevolved to retain high 
      selectivity of the ligand-receptor interaction. These paralogous forms have 
      become subfunctionalized, neofunctionalized, or dysfunctionalized during 
      evolution. This article reviews the evolutionary mechanism of GnRH/GnRHR and 
      KiSS/KiSSR, and the fate of the duplicated paralogs in vertebrates.
FAU - Kim, Dong-Kyu
AU  - Kim DK
AD  - Graduate School of Medicine, Korea University Seoul, South Korea.
FAU - Cho, Eun Bee
AU  - Cho EB
FAU - Moon, Mi Jin
AU  - Moon MJ
FAU - Park, Sumi
AU  - Park S
FAU - Hwang, Jong-Ik
AU  - Hwang JI
FAU - Do Rego, Jean-Luc
AU  - Do Rego JL
FAU - Vaudry, Hubert
AU  - Vaudry H
FAU - Seong, Jae Young
AU  - Seong JY
LA  - eng
PT  - Journal Article
DEP - 20120124
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC3265131
OTO - NOTNLM
OT  - G protein-coupled receptors
OT  - comparative genomics
OT  - evolution
OT  - gonadotropin-releasing hormone
OT  - kisspeptin
EDAT- 2012/02/01 06:00
MHDA- 2012/02/01 06:01
PMCR- 2012/01/01
CRDT- 2012/02/01 06:00
PHST- 2011/11/22 00:00 [received]
PHST- 2012/01/05 00:00 [accepted]
PHST- 2012/02/01 06:00 [entrez]
PHST- 2012/02/01 06:00 [pubmed]
PHST- 2012/02/01 06:01 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2012.00003 [doi]
PST - epublish
SO  - Front Neurosci. 2012 Jan 24;6:3. doi: 10.3389/fnins.2012.00003. eCollection 2012.