PMID- 22291799
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1896-9151 (Electronic)
IS  - 1734-1922 (Print)
IS  - 1734-1922 (Linking)
VI  - 7
IP  - 4
DP  - 2011 Aug
TI  - Changes in the activity of connective tissue matrix enzymes in the metabolic 
      syndrome.
PG  - 634-41
LID - 10.5114/aoms.2011.24133 [doi]
AB  - INTRODUCTION: Early atherosclerotic changes in the endothelium associated with 
      metabolic syndrome are generated with the participation of inflammatory cells, 
      cytokines and enzymes of the extracellular matrix. The study is aimed at a 
      comparison between the activity of inflammatory agents, tumour necrosis factor alpha 
      (TNF-alpha) and the enzymes of the connective tissue matrix in the blood of healthy 
      female patients as well as those suffering from the metabolic syndrome. MATERIAL 
      AND METHODS: The examination included 35 women with metabolic syndrome (MS). The 
      control group (C) comprised 35 healthy women. Lipidogram, C-reactive protein 
      level (CRP), fasting glucose level (FGL), matrix metalloproteinase (MMP)-8 and -9 
      activity, tissue inhibitor of metalloproteinase-1 (TIMP-1) and TNF-alpha levels in 
      blood were determined. RESULTS: As compared with the control group, the level of 
      inflammatory factors and the activity of extracellular matrix enzymes in the 
      metabolic syndrome were statistically higher (p < 0.05) and concerned the 
      following parameters: TNF-alpha (pg/ml): MS 6.59 +/-3.18, C 4.78 +/-2.91; CRP (mg/dl): MS 
      2.18 +/-2.04, C 1,26 +/-1.35; TIMP-1 (ng/ml): MS 265.5 +/-2.9, C 205.4 +/-72.6; MMP-9 
      (ng/ml): MS 198.2 +/-138.6, C 138.6 +/-116.1. Statistically significant correlations 
      were also found between TIMP-1 and the following factors: BMI (R = 0.400, p < 
      0.001), waist/hip ratio (WHR) (R = 0.278, p < 0.05), waistline (R = 0.417, p < 
      0.001), FGL (R = 0.290, p < 0.05), HDL cholesterol (R = -0.253, p < 0.05) and 
      triglycerides (R = 0.269, p < 0.05).There were positive correlations of MMP-9 
      with FGL (R = 0.446, p < 0.001) and waistline (R = 0.260, p < 0.05); MMP-8 with 
      FGL (R = 0.308, p < 0.05); and CRP with BMI (R = 0.370, p < 0.01), WHR (R = 
      0.325, p < 0.01) and waistline (R = 0.368, p < 0.01). CONCLUSIONS: Metabolic 
      syndrome is connected with higher activity of cytokines (TNF-alpha), inflammatory 
      markers (CRP) and matrix enzymes (MMP-9, MMP-8, TIMP-1).
FAU - Mieczkowska, Jolanta
AU  - Mieczkowska J
AD  - Chair and Department of Internal Medicine, Medical University of Lublin, Poland.
FAU - Mosiewicz, Jerzy
AU  - Mosiewicz J
FAU - Barud, Wojciech
AU  - Barud W
FAU - Kwasniewski, Wojciech
AU  - Kwasniewski W
LA  - eng
PT  - Journal Article
DEP - 20110902
PL  - Poland
TA  - Arch Med Sci
JT  - Archives of medical science : AMS
JID - 101258257
PMC - PMC3258777
OTO - NOTNLM
OT  - atherosclerosis
OT  - cytokines
OT  - metabolic syndrome
OT  - metalloproteinase
OT  - tissue inhibitors of metalloproteinases
EDAT- 2012/02/01 06:00
MHDA- 2012/02/01 06:01
PMCR- 2011/10/01
CRDT- 2012/02/01 06:00
PHST- 2009/11/20 00:00 [received]
PHST- 2010/01/15 00:00 [revised]
PHST- 2010/03/24 00:00 [accepted]
PHST- 2012/02/01 06:00 [entrez]
PHST- 2012/02/01 06:00 [pubmed]
PHST- 2012/02/01 06:01 [medline]
PHST- 2011/10/01 00:00 [pmc-release]
AID - AMS-7-4-634 [pii]
AID - 10.5114/aoms.2011.24133 [doi]
PST - ppublish
SO  - Arch Med Sci. 2011 Aug;7(4):634-41. doi: 10.5114/aoms.2011.24133. Epub 2011 Sep 
      2.