PMID- 22292305 OWN - NLM STAT- MEDLINE DCOM- 20120301 LR - 20120201 IS - 0001-4079 (Print) IS - 0001-4079 (Linking) VI - 195 IP - 3 DP - 2011 Mar TI - [Immune reconstitution inflammatory syndrome]. PG - 561-75; discussion 575 AB - The immune reconstitution inflammatory syndrome (IRIS), occurring in chronically HIV-infected patients, is a set of heterogeneous pathological manifestations attributed to an excessive and deregulated immune response to various pathogens and non infectious stimuli shortly after initiation of antiretroviral therapy. Mycobacteria and fungi are the main causes of IRIS, but many other pathogens and autoimmune/inflammatory disorders have also been incriminated Diagnosis is difficult and the optimal therapeutic strategy remains to be determined. Steroids have been recommended for tuberculosis-associated IRIS. Outcome is generally favorable, with the exception of central nervous system involvement. FAU - Breton, Guillaume AU - Breton G AD - Medecine interne 1, Hopital de la Pitie-Salpetriere, 47-83 bid de l'hopital, 75013 Paris. guillaume.breton@psl.aphp.fr LA - fre PT - English Abstract PT - Journal Article TT - Syndrome inflammatoire de reconstitution immune. PL - Netherlands TA - Bull Acad Natl Med JT - Bulletin de l'Academie nationale de medecine JID - 7503383 RN - 0 (Anti-Retroviral Agents) SB - IM MH - Anti-Retroviral Agents/adverse effects MH - HIV Infections/*complications/drug therapy MH - Humans MH - Immune Reconstitution Inflammatory Syndrome/diagnosis/*etiology EDAT- 2012/02/02 06:00 MHDA- 2012/03/02 06:00 CRDT- 2012/02/02 06:00 PHST- 2012/02/02 06:00 [entrez] PHST- 2012/02/02 06:00 [pubmed] PHST- 2012/03/02 06:00 [medline] PST - ppublish SO - Bull Acad Natl Med. 2011 Mar;195(3):561-75; discussion 575.