PMID- 22293352
OWN - NLM
STAT- MEDLINE
DCOM- 20120702
LR  - 20190720
IS  - 1347-5215 (Electronic)
IS  - 0918-6158 (Linking)
VI  - 35
IP  - 2
DP  - 2012
TI  - Natural vanadium-containing Jeju groundwater inhibits immunoglobulin E-mediated 
      anaphylactic reaction and suppresses eicosanoid generation and degranulation in 
      bone marrow derived-mast cells.
PG  - 216-22
AB  - The high-affinity receptor for immunoglobulin E (IgE) (FcepsilonRI)-mediated activation 
      of mast cells plays an important role in various allergic diseases. To assess the 
      anti-allergic activity of natural vanadium-containing Jeju groundwater (JW), an 
      in vivo passive cutaneous anaphylaxis (PCA) animal model and in vitro mouse bone 
      marrow-derived mast cells (BMMCs) was used. JW inhibited cyclooxygenase-2 
      (COX-2)-dependent prostaglandin D(2) (PGD(2)) generation in a dose-dependent 
      manner, with a concomitant reduction of COX-2 protein expression in IgE-induced 
      BMMCs. In addition, JW inhibited 5-lipoxygenase (5-LOX)-dependent generation of 
      leukotriene C(4) (LTC(4)) as well as degranulation in a dose-dependent manner. 
      These results demonstrate that JW has dual COX-2/5-LOX inhibitory activity. In 
      addition, vanadium pentoxide (V(2)O(5)), which is the major vanadium component of 
      JW, also inhibited PGD(2) and LTC(4) generation as well as degranulation in 
      IgE-induced BMMCs. Furthermore, oral administration of JW dose-dependently 
      inhibited mast cell-dependent passive anaphylactic reaction in IgE-sensitized 
      mice. Taken together, these results suggest that JW may be useful in regulating 
      mast cell-mediated allergic response through the suppression of eicosanoid 
      generation and degranulation in mast cells.
FAU - Li, Xian
AU  - Li X
AD  - College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.
FAU - Lu, Yue
AU  - Lu Y
FAU - Yang, Ju Hye
AU  - Yang JH
FAU - Jin, Ye
AU  - Jin Y
FAU - Hwang, Seung-Lark
AU  - Hwang SL
FAU - Chang, Hyeun Wook
AU  - Chang HW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Water Pollutants, Chemical)
RN  - 00J9J9XKDE (Vanadium)
RN  - 2CU6TT9V48 (Leukotriene C4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - RXY07S6CZ2 (Prostaglandin D2)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Anaphylaxis/drug therapy/immunology
MH  - Animals
MH  - Anti-Allergic Agents/*pharmacology
MH  - Bone Marrow Cells/cytology
MH  - Calcium/immunology
MH  - Cell Degranulation/drug effects
MH  - *Groundwater
MH  - Immunoglobulin E/immunology
MH  - Leukotriene C4/immunology
MH  - Male
MH  - Mast Cells/*drug effects/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred ICR
MH  - Prostaglandin D2/immunology
MH  - Vanadium/*pharmacology
MH  - Water Pollutants, Chemical/*pharmacology
EDAT- 2012/02/02 06:00
MHDA- 2012/07/03 06:00
CRDT- 2012/02/02 06:00
PHST- 2012/02/02 06:00 [entrez]
PHST- 2012/02/02 06:00 [pubmed]
PHST- 2012/07/03 06:00 [medline]
AID - JST.JSTAGE/bpb/35.216 [pii]
AID - 10.1248/bpb.35.216 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2012;35(2):216-22. doi: 10.1248/bpb.35.216.