PMID- 22293444
OWN - NLM
STAT- MEDLINE
DCOM- 20120625
LR  - 20220409
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 76
IP  - 4
DP  - 2012
TI  - Corosolic acid ameliorates atherosclerosis in apolipoprotein E-deficient mice by 
      regulating the nuclear factor-kappaB signaling pathway and inhibiting monocyte 
      chemoattractant protein-1 expression.
PG  - 995-1003
AB  - BACKGROUND: Corosolic acid (CRA) is a pentacyclic triterpene acid that has been 
      shown to exhibit an anti-atherosclerotic effect when added to diets of 
      low-density lipoprotein-deficient mice, but the mechanisms are unclear. The 
      purpose of the present study was to investigate the molecular mechanisms by which 
      CRA ameliorates atherosclerosis. METHODS AND RESULTS: The anti-atherosclerosis 
      effect of CRA in apolipoprotein E-deficient mice fed a Western-type diet was 
      evaluated using atherosclerosis lesion area, serum profiles, gene expression and 
      histological lesions. In vitro, the mechanisms responsible for the 
      anti-inflammatory effect of CRA were investigated on a lipopolysaccharide-induced 
      inflammation model. This model was also used to investigate in detail the effects 
      of CRA on gene expression and nuclear factor (NF)-kappaB activation. Compared with 
      the control group, the CRA-treated group exhibited a significant decrease in 
      atherosclerotic lesion area, as well as expression of monocyte chemoattractant 
      protein-1 (MCP-1) and CCR2. In vitro studies showed that CRA treatment 
      downregulated the mRNA levels of MCP-1, and inhibited monocyte adhesion and 
      migration, together with suppression of NF-kappaB signaling pathway. CONCLUSIONS: CRA 
      is capable of ameliorating atherosclerosis in apolipoprotein E-deficient mice by, 
      partly at least, inhibition of NF-kappaB activity along with decreased MCP-1 
      expression.
FAU - Chen, Hong
AU  - Chen H
AD  - State Key Laboratory of Natural Medicines, China Pharmaceutical University, 
      Nanjing, China.
FAU - Yang, Jie
AU  - Yang J
FAU - Zhang, Qin
AU  - Zhang Q
FAU - Chen, Li-Hong
AU  - Chen LH
FAU - Wang, Qiang
AU  - Wang Q
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120128
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Apolipoproteins E)
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (CCR2 protein, human)
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Ccr2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Lipids)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (NF-kappa B)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, CCR2)
RN  - 0 (Triterpenes)
RN  - AMX2I57A98 (corosolic acid)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - Aorta/*drug effects/immunology/metabolism/pathology
MH  - Aortic Diseases/blood/genetics/immunology/pathology/*prevention & control
MH  - Apolipoproteins E/*deficiency/genetics
MH  - Atherosclerosis/blood/genetics/immunology/pathology/*prevention & control
MH  - Biomarkers/blood
MH  - Cell Adhesion/drug effects
MH  - Cell Line
MH  - Cell Movement/drug effects
MH  - Chemokine CCL2/genetics/*metabolism
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Humans
MH  - Inflammation Mediators/metabolism
MH  - Lipids/blood
MH  - Lipopolysaccharides/pharmacology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Monocytes/drug effects/immunology/metabolism
MH  - NF-kappa B/*metabolism
MH  - RNA, Messenger/metabolism
MH  - Receptors, CCR2/genetics/metabolism
MH  - Signal Transduction/*drug effects
MH  - Time Factors
MH  - Triterpenes/*pharmacology
EDAT- 2012/02/02 06:00
MHDA- 2012/06/26 06:00
CRDT- 2012/02/02 06:00
PHST- 2012/02/02 06:00 [entrez]
PHST- 2012/02/02 06:00 [pubmed]
PHST- 2012/06/26 06:00 [medline]
AID - JST.JSTAGE/circj/CJ-11-0344 [pii]
AID - 10.1253/circj.cj-11-0344 [doi]
PST - ppublish
SO  - Circ J. 2012;76(4):995-1003. doi: 10.1253/circj.cj-11-0344. Epub 2012 Jan 28.