PMID- 22293447
OWN - NLM
STAT- MEDLINE
DCOM- 20120625
LR  - 20190819
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 76
IP  - 4
DP  - 2012
TI  - Prevalence and signal characteristics of late gadolinium enhancement on 
      contrast-enhanced magnetic resonance imaging in patients with takotsubo 
      cardiomyopathy.
PG  - 914-21
AB  - BACKGROUND: To determine the prevalence and signal intensity (SI) characteristics 
      of late gadolinium enhancement (LGE) on magnetic resonance imaging (MRI) in 
      takotsubo cardiomyopathy (TC). METHODS AND RESULTS: Cine, black-blood T2-weighted 
      and LGE MR images were acquired in 23 patients with TC within 72 h of onset. Wall 
      motion abnormality (WMA), edema and LGE were evaluated with a 16-segment model. 
      The SI characteristics of LGE were analyzed using SI distribution in remote 
      normal segments as reference. Follow-up MRI was performed 3 months later. 
      Retrospective analysis of LGE MRI was also performed in 10 patients with acute 
      myocardial infarction (AMI) to compare the SI characteristics between TC and AMI. 
      In acute phase, WMA and edema were observed in 236 (64%) and 205 (56%) of 368 
      segments. LGE was observed in 10 (2.7%) of 368 segments and in 5 (22%) of 23 
      patients. All LGE lesions in TC exhibited transmural enhancement. The 
      contrast-to-noise ratio (CNR) in TC was significantly lower than that of AMI 
      (3.1+/-0.3 standard deviations (SD) vs. 6.1+/-1.2 SD, P<0.01), and CNR value of 4 was 
      useful for distinguishing TC from AMI. Both LGE and WMA disappeared within 12 
      months. CONCLUSIONS: Grey myocardial signal on LGE MRI may be observed in 
      patients with TC. However, the extent of LGE is substantially less than that of 
      WMA and edema, and disappears within 12 months.
FAU - Nakamori, Shiro
AU  - Nakamori S
AD  - Department of Cardiology, Matsusaka Central Hospital, Matsusaka, Japan.
FAU - Matsuoka, Koji
AU  - Matsuoka K
FAU - Onishi, Katsuya
AU  - Onishi K
FAU - Kurita, Tairo
AU  - Kurita T
FAU - Ichikawa, Yasutaka
AU  - Ichikawa Y
FAU - Nakajima, Hiroshi
AU  - Nakajima H
FAU - Ishida, Masaki
AU  - Ishida M
FAU - Kitagawa, Kakuya
AU  - Kitagawa K
FAU - Tanigawa, Takashi
AU  - Tanigawa T
FAU - Nakamura, Tomoaki
AU  - Nakamura T
FAU - Ito, Masaaki
AU  - Ito M
FAU - Sakuma, Hajime
AU  - Sakuma H
LA  - eng
PT  - Journal Article
DEP - 20120127
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
CIN - Circ J. 2012;76(4):814-5. PMID: 22374150
MH  - Aged
MH  - Aged, 80 and over
MH  - *Contrast Media
MH  - Edema, Cardiac/diagnosis
MH  - Female
MH  - *Gadolinium DTPA
MH  - Humans
MH  - Japan
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Recovery of Function
MH  - Retrospective Studies
MH  - Takotsubo Cardiomyopathy/*diagnosis/physiopathology
MH  - Time Factors
MH  - Ventricular Function, Left
EDAT- 2012/02/02 06:00
MHDA- 2012/06/26 06:00
CRDT- 2012/02/02 06:00
PHST- 2012/02/02 06:00 [entrez]
PHST- 2012/02/02 06:00 [pubmed]
PHST- 2012/06/26 06:00 [medline]
AID - JST.JSTAGE/circj/CJ-11-1043 [pii]
AID - 10.1253/circj.cj-11-1043 [doi]
PST - ppublish
SO  - Circ J. 2012;76(4):914-21. doi: 10.1253/circj.cj-11-1043. Epub 2012 Jan 27.