PMID- 22293775
OWN - NLM
STAT- MEDLINE
DCOM- 20120601
LR  - 20211021
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Print)
IS  - 1791-2997 (Linking)
VI  - 5
IP  - 4
DP  - 2012 Apr
TI  - gamma-Tocotrienol attenuates TNF-alpha-induced changes in secretion and gene expression 
      of MCP-1, IL-6 and adiponectin in 3T3-L1 adipocytes.
PG  - 905-9
LID - 10.3892/mmr.2012.770 [doi]
AB  - Tocotrienols, members of the vitamin E family, have been shown to possess 
      anti-inflammatory properties and display activity against a variety of chronic 
      diseases, such as cancer, cardiovascular and neurological diseases. However, 
      whether tocotrienols contribute to the prevention of inflammatory responses in 
      adipose tissue remains to be elucidated. In this study, we examined the effects 
      of gamma-tocotrienol, the most common tocotrienol isomer, on tumor necrosis factor-alpha 
      (TNF-alpha)-induced inflammatory responses by measuring the expression of the 
      adipokines, monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6) and 
      adiponectin in 3T3-L1 adipocytes. Exposure to TNF-alpha (10 ng/ml) for 24 h increased 
      MCP-1 and IL-6 secretion, and decreased adiponectin secretion and peroxisome 
      proliferator-activated receptor-gamma (PPARgamma) mRNA expression. gamma-tocotrienol 
      effectively improved the TNF-alpha-induced adverse changes in MCP-1, IL-6 and 
      adiponectin secretion, and in MCP-1, IL-6, adiponectin and PPARgamma mRNA expression. 
      Furthermore, TNF-alpha-mediated IkappaB-alpha phosphorylation and nuclear factor-kappaB (NF-kappaB) 
      activation were significantly suppressed by the gamma-tocotrienol treatment. Our 
      results suggest that gamma-tocotrienol may improve obesity-related functional 
      abnormalities in adipocytes by attenuating NF-kappaB activation and the expression of 
      inflammatory adipokines.
FAU - Matsunaga, Tetsuro
AU  - Matsunaga T
AD  - Ajinomoto Integrative Research for Advanced Dieting, Graduate School of 
      Agriculture, Kyoto University, Kyoto, Japan.
FAU - Shoji, Ayae
AU  - Shoji A
FAU - Gu, Ning
AU  - Gu N
FAU - Joo, Erina
AU  - Joo E
FAU - Li, Shiho
AU  - Li S
FAU - Adachi, Tetsuya
AU  - Adachi T
FAU - Yamazaki, Hanae
AU  - Yamazaki H
FAU - Yasuda, Koichiro
AU  - Yasuda K
FAU - Kondoh, Takashi
AU  - Kondoh T
FAU - Tsuda, Kinsuke
AU  - Tsuda K
LA  - eng
PT  - Journal Article
DEP - 20120130
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (Adiponectin)
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chromans)
RN  - 0 (Interleukin-6)
RN  - 0 (NF-kappa B)
RN  - 0 (PPAR gamma)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Vitamins)
RN  - 1406-18-4 (Vitamin E)
RN  - 4382-43-8 (plastochromanol 8)
RN  - EC 2.7.11.10 (I-kappa B Kinase)
SB  - IM
MH  - 3T3-L1 Cells
MH  - Adipocytes/*drug effects/metabolism
MH  - Adiponectin/genetics/*metabolism
MH  - Animals
MH  - Chemokine CCL2/genetics/*metabolism
MH  - Chromans/*pharmacology
MH  - Gene Expression Regulation/*drug effects
MH  - I-kappa B Kinase/metabolism
MH  - Interleukin-6/genetics/*metabolism
MH  - Mice
MH  - NF-kappa B/metabolism
MH  - PPAR gamma/genetics/metabolism
MH  - Phosphorylation
MH  - Tumor Necrosis Factor-alpha/*pharmacology
MH  - Vitamin E/*analogs & derivatives/pharmacology
MH  - Vitamins/pharmacology
PMC - PMC3493080
EDAT- 2012/02/02 06:00
MHDA- 2012/06/02 06:00
PMCR- 2013/04/01
CRDT- 2012/02/02 06:00
PHST- 2011/08/23 00:00 [received]
PHST- 2011/12/22 00:00 [accepted]
PHST- 2012/02/02 06:00 [entrez]
PHST- 2012/02/02 06:00 [pubmed]
PHST- 2012/06/02 06:00 [medline]
PHST- 2013/04/01 00:00 [pmc-release]
AID - mmr-05-04-0905 [pii]
AID - 10.3892/mmr.2012.770 [doi]
PST - ppublish
SO  - Mol Med Rep. 2012 Apr;5(4):905-9. doi: 10.3892/mmr.2012.770. Epub 2012 Jan 30.