PMID- 22293928
OWN - NLM
STAT- MEDLINE
DCOM- 20120907
LR  - 20220408
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 96
IP  - 2
DP  - 2012 May
TI  - Serum fibroblast growth factor 21 was elevated in subjects with type 2 diabetes 
      mellitus and was associated with the presence of carotid artery plaques.
PG  - 196-203
LID - 10.1016/j.diabres.2012.01.004 [doi]
AB  - AIMS: Fibroblast growth factor 21 (FGF21) is an important regulator of 
      glucose/lipid metabolism. Although there are studies examining the relationship 
      between serum FGF21 levels and glucose homeostasis, the role of FGF21 remains 
      unclear. The objective of this study was to examine whether serum FGF21 levels 
      are associated with metabolic parameters in subjects with varying degrees of 
      obesity and glucose tolerance and with complications in subjects with type2 
      diabetes mellitus (T2DM). METHODS: The study consisted of 213 subjects who were 
      lean and had normal glucose tolerance (lean NGT), were overweight with NGT, had 
      impaired glucose tolerance (IGT) or had T2DM. Serum FGF21 levels and their 
      associations with the parameters of adiposity, glucose tolerance and the presence 
      of diabetic complications were examined. RESULTS: The serum FGF21 levels in T2DM 
      were higher than in lean NGT. Serum FGF21 levels showed a positive correlation 
      with the urine albumin-to-creatinine ratio (ACR) in all subjects except for the 
      T2DM subjects, who showed a correlation after adjustment of age, gender and body 
      mass index. Moreover, the subjects with carotid artery plaque showed higher serum 
      FGF21 levels than those without complications. CONCLUSION: Serum FGF21 levels 
      were associated with the urine ACR and diabetic complications including carotid 
      artery plaque.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - An, So-Yeon
AU  - An SY
AD  - Department of Endocrinology and Metabolism, Ajou University School of Medicine, 
      Suwon, Republic of Korea.
FAU - Lee, Min Suk
AU  - Lee MS
FAU - Yi, Sang-A
AU  - Yi SA
FAU - Ha, Eun Suk
AU  - Ha ES
FAU - Han, Seung Jin
AU  - Han SJ
FAU - Kim, Hae Jin
AU  - Kim HJ
FAU - Kim, Dae Jung
AU  - Kim DJ
FAU - Lee, Kwan-Woo
AU  - Lee KW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120130
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (fibroblast growth factor 21)
RN  - 62031-54-3 (Fibroblast Growth Factors)
SB  - IM
MH  - Adult
MH  - Carotid Stenosis/*blood
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Female
MH  - Fibroblast Growth Factors/*blood
MH  - Humans
MH  - Male
EDAT- 2012/02/02 06:00
MHDA- 2012/09/08 06:00
CRDT- 2012/02/02 06:00
PHST- 2011/10/17 00:00 [received]
PHST- 2011/12/19 00:00 [revised]
PHST- 2012/01/03 00:00 [accepted]
PHST- 2012/02/02 06:00 [entrez]
PHST- 2012/02/02 06:00 [pubmed]
PHST- 2012/09/08 06:00 [medline]
AID - S0168-8227(12)00005-8 [pii]
AID - 10.1016/j.diabres.2012.01.004 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2012 May;96(2):196-203. doi: 
      10.1016/j.diabres.2012.01.004. Epub 2012 Jan 30.