PMID- 22294240
OWN - NLM
STAT- Publisher
LR  - 20240227
IS  - 1432-1289 (Electronic)
IS  - 0020-9554 (Linking)
DP  - 2012 Feb 2
TI  - [Medicinal therapy of metastasized neuroendocrine tumors of the 
      gastroenteropancreatic system.].
AB  - Neuroendocrine neoplasms of the gastroenteropancreatic system are classified 
      according to the WHO classification system 2010 into neuroendocrine tumors (NET) 
      and neuroendocrine carcinomas (NEC). The proliferation index Ki-67 and the 
      grading of NETs is essential for the prognosis and therapy plan. Also NET tumor 
      biology and therapeutic options may differ depending on the primary NET tumor 
      location. Palliative therapy of inoperable NETs involves local ablative methods 
      in cases of primary liver metastasis, peptide receptor radionuclide therapy 
      (PRRT) in NETs expressing somatostatin receptors and different options for 
      medicinal therapy. This manuscript reviews the current role of biotherapy with 
      somatostatin analogues and interferon-alpha for symptom and tumor control. In 
      addition conventional chemotherapy regimens and novel molecular targeted 
      therapeutic options, such as sunitinib or everolimus in NET of the pancreas are 
      reviewed. Possible therapeutic algorithms are discussed.
FAU - Auernhammer, C J
AU  - Auernhammer CJ
AD  - Medizinische Klinik II, Campus Grosshadern, Klinikum der 
      Ludwig-Maximilians-Universitat Munchen, Marchioninistr. 15, 81377, Munchen, 
      Deutschland, christoph.auernhammer@med.uni-muenchen.de.
FAU - Spitzweg, C
AU  - Spitzweg C
FAU - Heinemann, V
AU  - Heinemann V
FAU - Goke, B
AU  - Goke B
LA  - ger
PT  - Journal Article
TT  - Medikamentose Therapie bei metastasierten neuroendokrinen Tumoren des 
      gastroenteropankreatischen Systems.
DEP - 20120202
PL  - Germany
TA  - Internist (Berl)
JT  - Der Internist
JID - 0264620
EDAT- 2012/02/02 06:00
MHDA- 2012/02/02 06:00
CRDT- 2012/02/02 06:00
PHST- 2012/02/02 06:00 [entrez]
PHST- 2012/02/02 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - 10.1007/s00108-011-2919-z [doi]
PST - aheadofprint
SO  - Internist (Berl). 2012 Feb 2. doi: 10.1007/s00108-011-2919-z.