PMID- 22296096 OWN - NLM STAT- MEDLINE DCOM- 20120814 LR - 20221207 IS - 1399-0039 (Electronic) IS - 0001-2815 (Linking) VI - 79 IP - 5 DP - 2012 May TI - Genetic variations in loci relevant to natural killer cell function are affected by ethnicity but are generally not correlated with susceptibility to HIV-1. PG - 367-71 LID - 10.1111/j.1399-0039.2012.01843.x [doi] AB - Polymorphisms in cell surface receptors of natural killer cells and their ligands on target cells can affect susceptibility to viral infections including human immunodeficiency virus (HIV)-1. We found that the carriage of the human leukocyte antigen (HLA)-G minus 14-bp polymorphism, LILRB1 single nucleotide polymorphism rs1061680, and activating and inhibitory killer immunoglobulin-like receptors (KIRs) were different when data were compared between Caucasian, African Americans and Asian populations. However, carriage was similar when HIV-1 patients were compared with control donors, with the exception of the African American cohort. CI - (c) 2012 John Wiley & Sons A/S. FAU - Aghafar, M Z K A AU - Aghafar MZ AD - School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Australia. FAU - Witt, C AU - Witt C FAU - Kamarulzaman, A AU - Kamarulzaman A FAU - Ismail, R AU - Ismail R FAU - Lederman, M M AU - Lederman MM FAU - Rodriguez, B AU - Rodriguez B FAU - Senitzer, D AU - Senitzer D FAU - Lee, S AU - Lee S FAU - Price, P AU - Price P LA - eng PT - Journal Article DEP - 20120202 PL - England TA - Tissue Antigens JT - Tissue antigens JID - 0331072 RN - 0 (Antigens, CD) RN - 0 (HLA-G Antigens) RN - 0 (LILRB1 protein, human) RN - 0 (Leukocyte Immunoglobulin-like Receptor B1) RN - 0 (Receptors, Immunologic) RN - 0 (Receptors, KIR) SB - IM MH - Adult MH - Antigens, CD/*genetics MH - Asian People MH - Black People MH - Case-Control Studies MH - Genetic Loci MH - Genetic Predisposition to Disease MH - HIV Infections/*genetics/immunology MH - HIV-1/physiology MH - HLA-G Antigens/*genetics MH - Humans MH - Killer Cells, Natural/immunology/metabolism MH - Leukocyte Immunoglobulin-like Receptor B1 MH - Polymorphism, Single Nucleotide MH - Receptors, Immunologic/*genetics MH - Receptors, KIR/*genetics/immunology MH - Sequence Analysis, DNA MH - Sequence Deletion MH - White People EDAT- 2012/02/03 06:00 MHDA- 2012/08/15 06:00 CRDT- 2012/02/03 06:00 PHST- 2012/02/03 06:00 [entrez] PHST- 2012/02/03 06:00 [pubmed] PHST- 2012/08/15 06:00 [medline] AID - 10.1111/j.1399-0039.2012.01843.x [doi] PST - ppublish SO - Tissue Antigens. 2012 May;79(5):367-71. doi: 10.1111/j.1399-0039.2012.01843.x. Epub 2012 Feb 2.