PMID- 22296119
OWN - NLM
STAT- MEDLINE
DCOM- 20120802
LR  - 20120426
IS  - 1651-2227 (Electronic)
IS  - 0803-5253 (Linking)
VI  - 101
IP  - 6
DP  - 2012 Jun
TI  - Simultaneous presence of human herpesvirus 6 and adenovirus infections in 
      intestinal intussusception of young children.
PG  - 663-70
LID - 10.1111/j.1651-2227.2012.02616.x [doi]
AB  - AIM: This prospective study investigated the role of viral infections in the 
      pathogenesis of intussusception, including human herpesvirus 6 (HHV-6), a known 
      lymphotropic virus. METHODS: Fifty-three children with intussusception treated in 
      hospital were enroled, and children of comparable age and gender served as 
      controls. Blood, stool and throat swab specimens, as well as mesenteric lymph 
      nodes and pieces of intestine from patients requiring surgery were tested for 
      various viruses by PCR methods. RESULTS: Altogether, 85% of intussusception cases 
      showed evidence of a recent or ongoing viral infection. Among the 53 
      intussusception cases, adenovirus was detected in 25 (47%), HHV-6 in 24 (45%), 
      rhinovirus in 12 (23%), cytomegalovirus in 7 (13%), enterovirus in 4 (8%) and 
      rotavirus in 3 (6%) patients. Of the 50 whole blood samples, 44% were positive 
      for HHV-6 and of the 16 resected mesenteric lymph nodes, 50% were positive for 
      HHV-6. Simultaneous presence of HHV-6 and adenovirus infection correlated 
      significantly with intussusception (OR 12.1, 95% CI 2.2 to 66.5). CONCLUSIONS: A 
      statistically significant association was observed between adenovirus and 
      childhood intussusception. HHV-6 was a common finding and occurred concomitantly 
      with other viruses. A simultaneous infection with HHV-6 and adenovirus carried 
      the highest risk for intussusception.
CI  - (c) 2012 The Author(s)/Acta Paediatrica (c) 2012 Foundation Acta Paediatrica.
FAU - Lappalainen, Suvi
AU  - Lappalainen S
AD  - Vaccine Research Center, University of Tampere Medical School, Tampere, Finland.
FAU - Ylitalo, Samuli
AU  - Ylitalo S
FAU - Arola, Anita
AU  - Arola A
FAU - Halkosalo, Anne
AU  - Halkosalo A
FAU - Rasanen, Sirpa
AU  - Rasanen S
FAU - Vesikari, Timo
AU  - Vesikari T
LA  - eng
PT  - Journal Article
DEP - 20120221
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
SB  - IM
MH  - Adenoviridae Infections/*complications
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Exanthema Subitum/*complications
MH  - Female
MH  - *Herpesvirus 6, Human
MH  - Humans
MH  - Infant
MH  - Intussusception/*virology
MH  - Male
MH  - Prospective Studies
EDAT- 2012/02/03 06:00
MHDA- 2012/08/03 06:00
CRDT- 2012/02/03 06:00
PHST- 2012/02/03 06:00 [entrez]
PHST- 2012/02/03 06:00 [pubmed]
PHST- 2012/08/03 06:00 [medline]
AID - 10.1111/j.1651-2227.2012.02616.x [doi]
PST - ppublish
SO  - Acta Paediatr. 2012 Jun;101(6):663-70. doi: 10.1111/j.1651-2227.2012.02616.x. 
      Epub 2012 Feb 21.