PMID- 22296171
OWN - NLM
STAT- MEDLINE
DCOM- 20120906
LR  - 20211021
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 79
IP  - 4
DP  - 2012 Apr
TI  - Multi-locus HLA class I and II allele and haplotype associations with follicular 
      lymphoma.
PG  - 279-86
LID - 10.1111/j.1399-0039.2012.01845.x [doi]
AB  - Follicular lymphoma (FL) is an indolent, sometimes, fatal disease characterized 
      by recurrence at progressively shorter intervals and is frequently refractive to 
      therapy. Genome-wide association studies have identified single nucleotide 
      polymorphisms (SNPs) in the human leukocyte antigen (HLA) region on chromosome 
      6p21.32-33 that are statistically significantly associated with FL risk. Low to 
      medium resolution typing of single or multiple HLA genes has provided an 
      incomplete picture of the total genetic risk imparted by this highly variable 
      region. To gain further insight into the role of HLA alleles in lymphomagenesis 
      and to investigate the independence of validated SNPs and HLA alleles with FL 
      risk, high-resolution HLA typing was conducted using next-generation sequencing 
      in 222 non-Hispanic White FL cases and 220 matched controls from a larger San 
      Francisco Bay Area population-based case-control study of lymphoma. A novel 
      protective association was found between the DPB1*03:01 allele and FL risk [odds 
      ratio (OR) = 0.39, 95% confidence interval (CI) = 0.21-0.68]. Extended haplotypes 
      DRB1*01:01-DQA1*01:01-DQB1*05:01 (OR = 2.01, 95% CI = 1.22-3.38) and 
      DRB1*15-DQA1*01-DQB1*06 (OR = 0.55, 95% CI = 0.36-0.82) also influenced FL risk. 
      Moreover, DRB1*15-DQA1*01-DQB1*06 was highly correlated with an established FL 
      risk locus, rs2647012. These results provide further insight into the critical 
      roles of HLA alleles and SNPs in FL pathogenesis that involve multi-locus effects 
      across the HLA region.
CI  - (c) 2012 John Wiley & Sons A/S.
FAU - Skibola, C F
AU  - Skibola CF
AD  - Division of Environmental Health Sciences, School of Public Health, University of 
      California, Berkeley, CA 94720-7356, USA. chrisfs@berkeley.edu
FAU - Akers, N K
AU  - Akers NK
FAU - Conde, L
AU  - Conde L
FAU - Ladner, M
AU  - Ladner M
FAU - Hawbecker, S K
AU  - Hawbecker SK
FAU - Cohen, F
AU  - Cohen F
FAU - Ribas, F
AU  - Ribas F
FAU - Erlich, H A
AU  - Erlich HA
FAU - Goodridge, D
AU  - Goodridge D
FAU - Trachtenberg, E A
AU  - Trachtenberg EA
FAU - Smith, M T
AU  - Smith MT
FAU - Bracci, P M
AU  - Bracci PM
LA  - eng
GR  - CA89745/CA/NCI NIH HHS/United States
GR  - CA154643-01A1/CA/NCI NIH HHS/United States
GR  - R01 CA122663-04/CA/NCI NIH HHS/United States
GR  - R01 CA122663-05/CA/NCI NIH HHS/United States
GR  - P42 ES004705/ES/NIEHS NIH HHS/United States
GR  - CA122663/CA/NCI NIH HHS/United States
GR  - R01 CA122663/CA/NCI NIH HHS/United States
GR  - CA104682/CA/NCI NIH HHS/United States
GR  - R01 CA154643/CA/NCI NIH HHS/United States
GR  - R01 CA122663-03/CA/NCI NIH HHS/United States
GR  - R01 CA104682/CA/NCI NIH HHS/United States
GR  - R01 CA104682-06/CA/NCI NIH HHS/United States
GR  - R01 CA122663-02/CA/NCI NIH HHS/United States
GR  - R01 CA104682-07/CA/NCI NIH HHS/United States
GR  - R01 CA045614/CA/NCI NIH HHS/United States
GR  - R03 CA089745/CA/NCI NIH HHS/United States
GR  - R01 CA154643-01A1/CA/NCI NIH HHS/United States
GR  - R01 CA104682-08/CA/NCI NIH HHS/United States
GR  - R01 CA122663-01/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120202
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Alleles
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Lymphoma, Follicular/*genetics
MH  - Male
MH  - Middle Aged
PMC - PMC3293942
MID - NIHMS350823
COIS- CONFLICTS OF INTEREST There are no conflicts of interest.
EDAT- 2012/02/03 06:00
MHDA- 2012/09/07 06:00
PMCR- 2013/04/01
CRDT- 2012/02/03 06:00
PHST- 2012/02/03 06:00 [entrez]
PHST- 2012/02/03 06:00 [pubmed]
PHST- 2012/09/07 06:00 [medline]
PHST- 2013/04/01 00:00 [pmc-release]
AID - 10.1111/j.1399-0039.2012.01845.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2012 Apr;79(4):279-86. doi: 10.1111/j.1399-0039.2012.01845.x. 
      Epub 2012 Feb 2.