PMID- 22296829
OWN - NLM
STAT- MEDLINE
DCOM- 20120815
LR  - 20211021
IS  - 1878-5905 (Electronic)
IS  - 0142-9612 (Print)
IS  - 0142-9612 (Linking)
VI  - 33
IP  - 11
DP  - 2012 Apr
TI  - Antitumor immunologically modified carbon nanotubes for photothermal therapy.
PG  - 3235-42
LID - 10.1016/j.biomaterials.2011.12.029 [doi]
AB  - An immunologically modified nanotube system was developed using an 
      immunoadjuvant, glycated chitosan (GC), as surfactant of single-walled carbon 
      nanotube (SWNTs). This SWNT-GC system not only retained both optical properties 
      of SWNTs and immunological functions of GC, but also could enter cells due to the 
      carrier properties of SWNTs. Cellular SWNTs induced thermal destruction of tumor 
      cells when irradiated by a near-infrared laser and, at the same time, cellular GC 
      could serve both as damage associated molecular pattern molecules (DAMPs) and 
      pathogen associated molecular pattern molecules (PAMPs) to enhance the tumor 
      immunogenicity and enhance the uptake and presentation of tumor antigens, leading 
      to special antitumor response. Using this system and a 980 nm laser, we treated 
      tumors, both in vitro and in vivo, and investigated the induced thermal and 
      immunological effects. Laser + SWNT-GC afford a remarkable efficacy in 
      suppressing tumor growth in animal cancer models, in many cases resulting in 
      complete tumor regression and long-term survival. Mice successfully treated by 
      Laser + SWNT-GC could establish resistance to tumor rechallenge. This system 
      forms a multifunctional temporal-spatial continuum, which can synergize 
      photothermal and immunological effects. The Laser + SWNT-GC could represent a 
      promising treatment modality to induce systemic antitumor response through a 
      local intervention, while minimizing the adverse side effects.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Zhou, Feifan
AU  - Zhou F
AD  - MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, 
      College of Biophotonics, South China Normal University, Guangzhou 510631, China.
FAU - Wu, Shengnan
AU  - Wu S
FAU - Song, Sheng
AU  - Song S
FAU - Chen, Wei R
AU  - Chen WR
FAU - Resasco, Daniel E
AU  - Resasco DE
FAU - Xing, Da
AU  - Xing D
LA  - eng
GR  - P20 RR016478/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120131
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Nanotubes, Carbon)
RN  - 9012-76-4 (Chitosan)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*administration & dosage/chemistry/immunology
MH  - Cell Line, Tumor
MH  - Chitosan/*chemistry/immunology/*therapeutic use
MH  - Female
MH  - Low-Level Light Therapy/*methods
MH  - Mammary Neoplasms, Animal/*immunology/pathology/*therapy
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Nanotubes, Carbon/*chemistry
MH  - Treatment Outcome
PMC - PMC5987227
MID - NIHMS969240
EDAT- 2012/02/03 06:00
MHDA- 2012/08/16 06:00
PMCR- 2018/06/05
CRDT- 2012/02/03 06:00
PHST- 2011/12/01 00:00 [received]
PHST- 2011/12/13 00:00 [accepted]
PHST- 2012/02/03 06:00 [entrez]
PHST- 2012/02/03 06:00 [pubmed]
PHST- 2012/08/16 06:00 [medline]
PHST- 2018/06/05 00:00 [pmc-release]
AID - S0142-9612(11)01499-2 [pii]
AID - 10.1016/j.biomaterials.2011.12.029 [doi]
PST - ppublish
SO  - Biomaterials. 2012 Apr;33(11):3235-42. doi: 10.1016/j.biomaterials.2011.12.029. 
      Epub 2012 Jan 31.