PMID- 22297318
OWN - NLM
STAT- MEDLINE
DCOM- 20120322
LR  - 20120202
IS  - 1539-736X (Electronic)
IS  - 0022-3018 (Linking)
VI  - 200
IP  - 2
DP  - 2012 Feb
TI  - A bidimensional solution for outcomes in bipolar disorder.
PG  - 180-2
LID - 10.1097/NMD.0b013e3182439885 [doi]
AB  - Although depressive symptoms have been consistently associated with lower quality 
      of life and increased disability in bipolar disorder, their relation to manic 
      symptoms is not as clear cut. A great overlap between these outcomes complicates 
      the understanding of how they cluster together. We used exploratory factor 
      analysis to clarify the relation between these constructs. We consecutively 
      recruited 320 patients with bipolar disorder, and interviewers rated the Hamilton 
      Depression and Anxiety Rating Scales, the Young Mania Rating Scale (YMRS), 
      Clinical Global Impression (CGI), and the Global Assessment of Functioning (GAF). 
      The self-rated Sheehan Disability Scale and the World Health Organization Quality 
      of Life-BREF questionnaires were also collected. Two distinct and large 
      dimensions emerged. Depression and anxiety, along with the self-rated scales, 
      loaded in the first factor, whereas the YMRS, the GAF, and the CGI loaded in the 
      second. These findings imply that evaluating self- and observer-rated outcomes 
      may make up for a more thorough evaluation because each conveys unique illness 
      information.
FAU - Magalhaes, Pedro V S
AU  - Magalhaes PV
AD  - Bipolar Disorders Program, INCT Translational Medicine & Molecular Psychiatry 
      Laboratory, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio 
      Grande do Sul, Porto Alegre, Brazil.
FAU - Manzolli, Patricia
AU  - Manzolli P
FAU - Walz, Julio C
AU  - Walz JC
FAU - Kapczinski, Flavio
AU  - Kapczinski F
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nerv Ment Dis
JT  - The Journal of nervous and mental disease
JID - 0375402
SB  - IM
MH  - Adult
MH  - Bipolar Disorder/diagnosis/*psychology/*therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Psychiatric Status Rating Scales
MH  - Treatment Outcome
EDAT- 2012/02/03 06:00
MHDA- 2012/03/23 06:00
CRDT- 2012/02/03 06:00
PHST- 2012/02/03 06:00 [entrez]
PHST- 2012/02/03 06:00 [pubmed]
PHST- 2012/03/23 06:00 [medline]
AID - 00005053-201202000-00012 [pii]
AID - 10.1097/NMD.0b013e3182439885 [doi]
PST - ppublish
SO  - J Nerv Ment Dis. 2012 Feb;200(2):180-2. doi: 10.1097/NMD.0b013e3182439885.