PMID- 22297491
OWN - NLM
STAT- MEDLINE
DCOM- 20120503
LR  - 20220310
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 53
IP  - 3
DP  - 2012 Mar 21
TI  - Automated assessment of drusen using three-dimensional spectral-domain optical 
      coherence tomography.
PG  - 1576-83
LID - 10.1167/iovs.11-8103 [doi]
AB  - PURPOSE: To compare automated assessment of macular drusen delineated by the 
      authors' originally developed algorithm on three-dimensional (3D) spectral-domain 
      optical coherence tomography (SD-OCT) with the assessment by certified graders on 
      color fundus photographs in nonneovascular age-related macular degeneration 
      (AMD). METHODS: Automated assessment of macular drusen was performed using raster 
      scan by 3D OCT scans in 18 eyes with nonneovascular AMD with at least one large 
      druse (>/=125 mum) and predominantly soft indistinct drusen. Drusen was defined as 
      the regions that have the distance between the retinal pigment epithelium and 
      calculated Bruch's membrane lines > predefined threshold distances. The agreement 
      was assessed on maximum drusen size and drusen area within grid between 3D SD-OCT 
      and color fundus photographs, and false-negative and false-positive drusen at 
      each threshold distance. RESULTS: There was agreement or agreement within one 
      step in all eyes in maximum drusen size, and 15 (83.3%) of the eyes in the drusen 
      area, except 6 pixels, regardless of threshold distances. However, the number of 
      eyes with exact agreement in the drusen area increased when the threshold 
      distances were smaller than 4 pixels. In the three cases with disagreement in the 
      drusen area, false-negative drusen on 3D SD-OCT were characterized by being small 
      in area and height. CONCLUSIONS: Automated assessment of drusen parameters based 
      on the authors' algorithm on 3D SD-OCT, which was limited by the poor detection 
      ability of small drusen, showed good agreement with the assessment by certified 
      graders on color fundus photography in these subjects.
FAU - Iwama, Daisuke
AU  - Iwama D
AD  - Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School 
      of Medicine, Kyoto, Japan.
FAU - Hangai, Masanori
AU  - Hangai M
FAU - Ooto, Sotaro
AU  - Ooto S
FAU - Sakamoto, Atsushi
AU  - Sakamoto A
FAU - Nakanishi, Hideo
AU  - Nakanishi H
FAU - Fujimura, Takashi
AU  - Fujimura T
FAU - Domalpally, Amitha
AU  - Domalpally A
FAU - Danis, Ronald P
AU  - Danis RP
FAU - Yoshimura, Nagahisa
AU  - Yoshimura N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120321
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Algorithms
MH  - *Diagnostic Techniques, Ophthalmological
MH  - Female
MH  - Humans
MH  - Japan
MH  - Macular Degeneration/*diagnosis
MH  - Male
MH  - Prospective Studies
MH  - Retinal Drusen/*diagnosis
MH  - Tomography, Optical Coherence/*methods
EDAT- 2012/02/03 06:00
MHDA- 2012/05/04 06:00
CRDT- 2012/02/03 06:00
PHST- 2012/02/03 06:00 [entrez]
PHST- 2012/02/03 06:00 [pubmed]
PHST- 2012/05/04 06:00 [medline]
AID - iovs.11-8103 [pii]
AID - 10.1167/iovs.11-8103 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2012 Mar 21;53(3):1576-83. doi: 10.1167/iovs.11-8103.