PMID- 22298838
OWN - NLM
STAT- MEDLINE
DCOM- 20120412
LR  - 20211021
IS  - 1460-2105 (Electronic)
IS  - 0027-8874 (Print)
IS  - 0027-8874 (Linking)
VI  - 104
IP  - 4
DP  - 2012 Feb 22
TI  - Flexible sigmoidoscopy in the randomized prostate, lung, colorectal, and ovarian 
      (PLCO) cancer screening trial: added yield from a second screening examination.
PG  - 280-9
LID - 10.1093/jnci/djr549 [doi]
AB  - BACKGROUND: Among randomized trials evaluating flexible sigmoidoscopy (FSG) for 
      its effect on colorectal cancer mortality, only the Prostate, Lung, Colorectal, 
      and Ovarian (PLCO) Cancer Screening Trial screened its participants more than one 
      time. We report outcomes from the PLCO screening FSG program and evaluate the 
      increased yield produced by a second FSG. METHODS: Participants were screened by 
      60-cm FSG in 10 regional screening centers at study entry and 3 or 5 years later, 
      depending on the time of random assignment. Results from subsequent diagnostic 
      intervention were tracked and recorded in a standardized fashion, and outcomes 
      were compared according to sex and age. The protocol discouraged repeat FSG in 
      persons with colorectal cancer or adenoma diagnosed after the initial FSG. 
      RESULTS: Of 77 447 enrollees, 67 073 (86.6%) had at least one FSG and 39 443 
      (50.9%) had two FSGs. Diagnostic intervention occurred in 74.9% after a positive 
      first FSG and in 78.7% after a positive repeat FSG. The second FSG increased the 
      screening yield by 32%: Colorectal cancer or advanced adenoma was detected in 
      37.8 per 1000 persons after first screening and in 49.8 per 1000 persons after 
      all screenings. The second FSG increased the yield of cancer or advanced adenoma 
      by 26% in women and by 34% in men. Of 223 subjects who received a diagnosis of 
      colorectal carcinoma within 1 year of a positive FSG, 64.6% had stage I and 17.5% 
      had stage II disease. CONCLUSIONS: Repeat FSG increased the detection of 
      colorectal cancer or advanced adenoma in women by one-fourth and in men by 
      one-third. Screen-detected carcinomas were early stage (stage I or II) in greater 
      than 80% of screened persons. Colorectal cancer mortality data from the PLCO, as 
      the definitive endpoint, will follow in later publications.
FAU - Weissfeld, Joel L
AU  - Weissfeld JL
AD  - UPMC Cancer Pavilion (POB II), Pittsburgh, PA 15232, USA. jwepid@pitt.edu
FAU - Schoen, Robert E
AU  - Schoen RE
FAU - Pinsky, Paul F
AU  - Pinsky PF
FAU - Bresalier, Robert S
AU  - Bresalier RS
FAU - Doria-Rose, V Paul
AU  - Doria-Rose VP
FAU - Laiyemo, Adeyinka O
AU  - Laiyemo AO
FAU - Church, Timothy
AU  - Church T
FAU - Yokochi, Lance A
AU  - Yokochi LA
FAU - Yurgalevitch, Susan
AU  - Yurgalevitch S
FAU - Rathmell, Joshua
AU  - Rathmell J
FAU - Andriole, Gerald L
AU  - Andriole GL
FAU - Buys, Saundra
AU  - Buys S
FAU - Crawford, E David
AU  - Crawford ED
FAU - Fouad, Mona
AU  - Fouad M
FAU - Isaacs, Claudine
AU  - Isaacs C
FAU - Lamerato, Lois
AU  - Lamerato L
FAU - Reding, Douglas
AU  - Reding D
FAU - Prorok, Philip C
AU  - Prorok PC
FAU - Berg, Christine D
AU  - Berg CD
CN  - PLCO Project Team
LA  - eng
GR  - N01-CN-25524/CN/NCI NIH HHS/United States
GR  - N01-CN-25513/CN/NCI NIH HHS/United States
GR  - N01-CN-25511/CN/NCI NIH HHS/United States
GR  - N01-CN-75022/CN/NCI NIH HHS/United States
GR  - N01-CN-25514/CN/NCI NIH HHS/United States
GR  - N01-CN-25512/CN/NCI NIH HHS/United States
GR  - N01-CN-25515/CN/NCI NIH HHS/United States
GR  - N01-CN-25404/CN/NCI NIH HHS/United States
GR  - N01-CN-25516/CN/NCI NIH HHS/United States
GR  - N01-CN-25476/CN/NCI NIH HHS/United States
GR  - N01-CN-25518/CN/NCI NIH HHS/United States
GR  - N01-CN-25522/CN/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120131
PL  - United States
TA  - J Natl Cancer Inst
JT  - Journal of the National Cancer Institute
JID - 7503089
SB  - IM
CIN - J Natl Cancer Inst. 2012 Feb 22;104(4):259-60. PMID: 22298837
MH  - Adenoma/diagnosis
MH  - Adult
MH  - Age Distribution
MH  - Age Factors
MH  - Aged
MH  - Carcinoma/diagnosis
MH  - Colorectal Neoplasms/*diagnosis/*epidemiology/mortality/pathology
MH  - *Early Detection of Cancer
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/diagnosis
MH  - Male
MH  - Mass Screening/*methods
MH  - Middle Aged
MH  - Ovarian Neoplasms/diagnosis
MH  - Prostatic Neoplasms/diagnosis
MH  - Randomized Controlled Trials as Topic
MH  - Sex Distribution
MH  - Sex Factors
MH  - *Sigmoidoscopy/instrumentation
PMC - PMC3283538
EDAT- 2012/02/03 06:00
MHDA- 2012/04/13 06:00
PMCR- 2013/02/22
CRDT- 2012/02/03 06:00
PHST- 2012/02/03 06:00 [entrez]
PHST- 2012/02/03 06:00 [pubmed]
PHST- 2012/04/13 06:00 [medline]
PHST- 2013/02/22 00:00 [pmc-release]
AID - djr549 [pii]
AID - 10.1093/jnci/djr549 [doi]
PST - ppublish
SO  - J Natl Cancer Inst. 2012 Feb 22;104(4):280-9. doi: 10.1093/jnci/djr549. Epub 2012 
      Jan 31.