PMID- 22300473
OWN - NLM
STAT- MEDLINE
DCOM- 20120614
LR  - 20220317
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Print)
IS  - 0002-9394 (Linking)
VI  - 153
IP  - 5
DP  - 2012 May
TI  - Characterization of diabetic microaneurysms by simultaneous fluorescein 
      angiography and spectral-domain optical coherence tomography.
PG  - 861-867.e1
LID - 10.1016/j.ajo.2011.10.005 [doi]
AB  - PURPOSE: To correlate spectral-domain optical coherence tomography (SD-OCT) 
      findings of perfused diabetic microaneurysms with leakage status on fluorescein 
      angiography (FA) using simultaneous FA and SD-OCT. DESIGN: Retrospective, 
      observational case series. METHODS: A total of 173 microaneurysms were analyzed 
      in 50 eyes (14 mild nonproliferative diabetic retinopathy [NPDR]; 22 moderate 
      NPDR; 9 severe NPDR; 5 proliferative diabetic retinopathy) of 40 diabetic 
      patients using simultaneous FA and SD-OCT. The characteristics of microaneurysms 
      were evaluated by 2 masked observers using SD-OCT and correlated with leakage 
      status on FA. RESULTS: External diameter of microaneurysms averaged 104 mum (range 
      43-266 mum). Some microaneurysm centers (15/173; 9%) and the outermost extent of 
      microaneurysms (113/173; 68%) were localized to the outer half of the retina. 
      Almost all microaneurysms spanned more than 1 retinal layer (157/173; 91%). Most 
      microaneurysms had an internal lumen with homogeneous reflectivity (109/173; 63%) 
      and moderate reflectivity (87/173; 50%). Retinal thickness through microaneurysms 
      as well as the presence of adjacent hyporeflectivity on SD-OCT correlated with 
      increasing leakage status seen on FA (P < .001). Microaneurysm dimensions, 
      percent depth within the retina, retinal layer location, and internal 
      reflectivity by SD-OCT did not correlate significantly with FA leakage status. 
      CONCLUSIONS: Simultaneous FA and SD-OCT allows detailed characterization of 
      perfused diabetic microaneurysms. Increased FA leakage of diabetic microaneurysms 
      positively correlated with perianeurysm fluid and retinal thickness. Perfused 
      microaneurysms seen by SD-OCT were localized deeper than the inner nuclear layer.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Wang, Haiyan
AU  - Wang H
AD  - Jacobs Retina Center at Shiley Eye Center, University of California, San Diego, 
      La Jolla, USA.
FAU - Chhablani, Jay
AU  - Chhablani J
FAU - Freeman, William R
AU  - Freeman WR
FAU - Chan, Candy K
AU  - Chan CK
FAU - Kozak, Igor
AU  - Kozak I
FAU - Bartsch, Dirk-Uwe
AU  - Bartsch DU
FAU - Cheng, Lingyun
AU  - Cheng L
LA  - eng
GR  - EY07366/EY/NEI NIH HHS/United States
GR  - R01 EY020617/EY/NEI NIH HHS/United States
GR  - R01 EY016323/EY/NEI NIH HHS/United States
GR  - R01 EY020617-01A1/EY/NEI NIH HHS/United States
GR  - EY01323/EY/NEI NIH HHS/United States
GR  - R01 EY001323/EY/NEI NIH HHS/United States
GR  - R01 EY007366/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120201
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Aneurysm/*diagnosis
MH  - Capillary Permeability
MH  - Diabetic Retinopathy/*diagnosis
MH  - *Fluorescein Angiography
MH  - Humans
MH  - Retina/pathology
MH  - Retinal Vessels/*pathology
MH  - Retrospective Studies
MH  - *Tomography, Optical Coherence
MH  - Visual Acuity/physiology
PMC - PMC3331899
MID - NIHMS331413
EDAT- 2012/02/04 06:00
MHDA- 2012/06/15 06:00
PMCR- 2013/05/01
CRDT- 2012/02/04 06:00
PHST- 2011/06/28 00:00 [received]
PHST- 2011/10/05 00:00 [revised]
PHST- 2011/10/06 00:00 [accepted]
PHST- 2012/02/04 06:00 [entrez]
PHST- 2012/02/04 06:00 [pubmed]
PHST- 2012/06/15 06:00 [medline]
PHST- 2013/05/01 00:00 [pmc-release]
AID - S0002-9394(11)00779-3 [pii]
AID - 10.1016/j.ajo.2011.10.005 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2012 May;153(5):861-867.e1. doi: 10.1016/j.ajo.2011.10.005. Epub 
      2012 Feb 1.