PMID- 22300776 OWN - NLM STAT- MEDLINE DCOM- 20120531 LR - 20220317 IS - 1532-8414 (Electronic) IS - 1071-9164 (Linking) VI - 18 IP - 2 DP - 2012 Feb TI - Indications for cardiac resynchronization therapy: 2011 update from the Heart Failure Society of America Guideline Committee. PG - 94-106 LID - 10.1016/j.cardfail.2011.12.004 [doi] AB - Cardiac resynchronization therapy (CRT) improves survival, symptoms, quality of life, exercise capacity, and cardiac structure and function in patients with New York Heart Association (NYHA) functional class II or ambulatory class IV heart failure (HF) with wide QRS complex. The totality of evidence supports the use of CRT in patients with less severe HF symptoms. CRT is recommended for patients in sinus rhythm with a widened QRS interval (>/=150 ms) not due to right bundle branch block (RBBB) who have severe left ventricular (LV) systolic dysfunction and persistent NYHA functional class II-III symptoms despite optimal medical therapy (strength of evidence A). CRT may be considered for several other patient groups for whom evidence of benefit is clinically significant but less substantial, including patients with a QRS interval of >/=120 to <150 ms and severe LV systolic dysfunction who have persistent mild to severe HF despite optimal medical therapy (strength of evidence B), some patients with atrial fibrillation, and some with ambulatory class IV HF. Several evidence gaps remain that need to be addressed, including the ideal threshold for QRS duration, QRS morphology, lead placement, degree of myocardial scarring, and the modality for evaluating dyssynchrony. Recommendations will evolve over time as additional data emerge from completed and ongoing clinical trials. CI - Copyright (c) 2012 Elsevier Inc. All rights reserved. FAU - Stevenson, William G AU - Stevenson WG AD - Department of Medicine, Division of Cardiology Brigham and Women's Hospital, Boston, Massachusetts, USA. FAU - Hernandez, Adrian F AU - Hernandez AF FAU - Carson, Peter E AU - Carson PE FAU - Fang, James C AU - Fang JC FAU - Katz, Stuart D AU - Katz SD FAU - Spertus, John A AU - Spertus JA FAU - Sweitzer, Nancy K AU - Sweitzer NK FAU - Tang, W H Wilson AU - Tang WH FAU - Albert, Nancy M AU - Albert NM FAU - Butler, Javed AU - Butler J FAU - Westlake Canary, Cheryl A AU - Westlake Canary CA FAU - Collins, Sean P AU - Collins SP FAU - Colvin-Adams, Monica AU - Colvin-Adams M FAU - Ezekowitz, Justin A AU - Ezekowitz JA FAU - Givertz, Michael M AU - Givertz MM FAU - Hershberger, Ray E AU - Hershberger RE FAU - Rogers, Joseph G AU - Rogers JG FAU - Teerlink, John R AU - Teerlink JR FAU - Walsh, Mary N AU - Walsh MN FAU - Stough, Wendy Gattis AU - Stough WG FAU - Starling, Randall C AU - Starling RC CN - Heart Failure Society of America Guideline Committee LA - eng PT - Journal Article PT - Practice Guideline PT - Research Support, N.I.H., Extramural PT - Research Support, U.S. Gov't, Non-P.H.S. PL - United States TA - J Card Fail JT - Journal of cardiac failure JID - 9442138 SB - IM MH - *Cardiac Pacing, Artificial MH - *Cardiac Resynchronization Therapy MH - Cardiology MH - Heart Failure/*therapy MH - Humans MH - Societies, Medical MH - United States FIR - Yano, Cheryl IR - Yano C FIR - Galle, Bart IR - Galle B FIR - Massie, Barry M IR - Massie BM FIR - Force, Thomas IR - Force T FIR - Sabbah, Hani N IR - Sabbah HN FIR - Mehra, Mandeep R IR - Mehra MR FIR - Mann, Douglas L IR - Mann DL FIR - Anand, Inder S IR - Anand IS FIR - Burnett, John C Jr IR - Burnett JC Jr FIR - Chin, John IR - Chin J FIR - Houser, Steven R IR - Houser SR FIR - Hunt, Sharon A IR - Hunt SA FIR - Jessup, Mariell L IR - Jessup ML FIR - Lindenfeld, JoAnn IR - Lindenfeld J FIR - Paul, Sara C IR - Paul SC FIR - Piano, Mariann IR - Piano M FIR - Ross, Heather J IR - Ross HJ FIR - Udelson, James E IR - Udelson JE FIR - Zile, Michael R IR - Zile MR EDAT- 2012/02/04 06:00 MHDA- 2012/06/01 06:00 CRDT- 2012/02/04 06:00 PHST- 2011/12/08 00:00 [received] PHST- 2011/12/09 00:00 [accepted] PHST- 2012/02/04 06:00 [entrez] PHST- 2012/02/04 06:00 [pubmed] PHST- 2012/06/01 06:00 [medline] AID - S1071-9164(11)01322-4 [pii] AID - 10.1016/j.cardfail.2011.12.004 [doi] PST - ppublish SO - J Card Fail. 2012 Feb;18(2):94-106. doi: 10.1016/j.cardfail.2011.12.004.