PMID- 22300812
OWN - NLM
STAT- MEDLINE
DCOM- 20120806
LR  - 20120326
IS  - 1095-9572 (Electronic)
IS  - 1053-8119 (Linking)
VI  - 60
IP  - 3
DP  - 2012 Apr 15
TI  - Functional activity of the right temporo-parietal junction and of the medial 
      prefrontal cortex associated with true and false belief reasoning.
PG  - 1652-61
LID - 10.1016/j.neuroimage.2012.01.073 [doi]
AB  - Since false belief reasoning requires mental state representation independently 
      of the state of reality, it is seen as a key ability in Theory of Mind (ToM). 
      Although true beliefs do not have to be processed independently of the state of 
      reality, growing behavioural evidence indicates that true belief reasoning is 
      different from just reasoning about the state of reality. So far, neural studies 
      on true and false belief reasoning revealed inconsistent findings in the medial 
      prefrontal cortex (MPFC) and in the right temporo-parietal junction (R-TPJ), 
      brain regions that are hypothesized to play an important role in ToM. To further 
      explore true and false belief reasoning, the present functional magnetic 
      resonance imaging (fMRI) study in eighteen adult subjects used methodological 
      refinements such as ensuring that the true belief trials did not elicit false 
      belief reasoning, as well as including paralleled control conditions requiring 
      reasoning about the state of reality. When compared to its control condition, 
      common R-TPJ activity was observed for true and false belief reasoning, 
      supporting its role in belief reasoning in general, and indicating that, at least 
      in adults, also true belief reasoning appears to be different from reasoning 
      about the state of reality. Differential activity was observed in a broad network 
      of brain regions such as the MPFC, the inferior frontal cortex, and the 
      precuneus. False over true belief reasoning induced activation in the posterior 
      MPFC (pMPFC), supporting its role in the decoupling mechanisms, which is defined 
      as processing a mental state independently of the state of reality.
CI  - Copyright A(c) 2012 Elsevier Inc. All rights reserved.
FAU - Dohnel, Katrin
AU  - Dohnel K
AD  - Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, 
      Germany. katrin.doehnel@medbo.de
FAU - Schuwerk, Tobias
AU  - Schuwerk T
FAU - Meinhardt, Jorg
AU  - Meinhardt J
FAU - Sodian, Beate
AU  - Sodian B
FAU - Hajak, Goran
AU  - Hajak G
FAU - Sommer, Monika
AU  - Sommer M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120121
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain Mapping
MH  - Cognition/*physiology
MH  - *Concept Formation
MH  - *Culture
MH  - Decision Making/physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Neural Pathways/physiology
MH  - Parietal Lobe/*physiology
MH  - Prefrontal Cortex/*physiology
MH  - *Reality Testing
MH  - Temporal Lobe/*physiology
MH  - Theory of Mind/physiology
MH  - Trust
MH  - Young Adult
EDAT- 2012/02/04 06:00
MHDA- 2012/08/07 06:00
CRDT- 2012/02/04 06:00
PHST- 2011/10/21 00:00 [received]
PHST- 2011/12/27 00:00 [revised]
PHST- 2012/01/11 00:00 [accepted]
PHST- 2012/02/04 06:00 [entrez]
PHST- 2012/02/04 06:00 [pubmed]
PHST- 2012/08/07 06:00 [medline]
AID - S1053-8119(12)00090-0 [pii]
AID - 10.1016/j.neuroimage.2012.01.073 [doi]
PST - ppublish
SO  - Neuroimage. 2012 Apr 15;60(3):1652-61. doi: 10.1016/j.neuroimage.2012.01.073. 
      Epub 2012 Jan 21.