PMID- 22301835
OWN - NLM
STAT- MEDLINE
DCOM- 20120529
LR  - 20160523
IS  - 1664-2155 (Electronic)
IS  - 1664-2147 (Linking)
VI  - 69
DP  - 2011
TI  - Metabolic regulation of fat use during exercise and in recovery.
PG  - 39-53; discussion 53-8
LID - 10.1159/000329281 [doi]
AB  - Fat is an important fuel for exercise but plays a secondary role to carbohydrate 
      (CHO). Increasing fat use during exercise can decrease the reliance on CHO and 
      spare CHO for later in training sessions or competitions that depend on CHO for 
      success. The pathways that metabolize and oxidize fat are activated more slowly 
      than CHO at the onset of exercise and reach a maximum at moderate exercise 
      intensities. As exercise intensity increases to  approximately 75% VO(2max) and beyond, fat 
      metabolism is inhibited: using CHO will increase the amount of energy produced 
      per liter of oxygen consumed. The capacity for fat use during exercise is 
      increased by aerobic training and the dietary combination of little or no CHO 
      intake and high fat intake. Fat oxidation is very dependent on the mitochondrial 
      volume of muscle but other key sites of regulation include release of fat from 
      storage forms and fat transport across plasma and mitochondrial membranes. This 
      chapter examines the control of fat metabolism during moderate and intense 
      exercise with an emphasis on human findings and the adaptations that occur with 
      aerobic training and other acute nutritional manipulations. Recent work using 
      molecular and cellular compartmentalization techniques have advanced the 
      knowledge in this area.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Spriet, Lawrence L
AU  - Spriet LL
AD  - Department of Human Health and Nutritional Science, University of Guelph, Guelph, 
      ON, Canada.
LA  - eng
PT  - Journal Article
DEP - 20120118
PL  - Switzerland
TA  - Nestle Nutr Inst Workshop Ser
JT  - Nestle Nutrition Institute workshop series
JID - 101577268
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
SB  - IM
MH  - *Adaptation, Physiological
MH  - Diet
MH  - Dietary Carbohydrates/administration & dosage/metabolism
MH  - Dietary Fats/*administration & dosage/metabolism
MH  - Energy Metabolism/*physiology
MH  - Exercise/*physiology
MH  - Humans
MH  - *Lipid Metabolism
MH  - Muscle, Skeletal/metabolism
MH  - Oxidation-Reduction
MH  - Oxygen Consumption/physiology
EDAT- 2012/02/04 06:00
MHDA- 2012/05/30 06:00
CRDT- 2012/02/04 06:00
PHST- 2012/02/04 06:00 [entrez]
PHST- 2012/02/04 06:00 [pubmed]
PHST- 2012/05/30 06:00 [medline]
AID - 329279 [pii]
AID - 10.1159/000329281 [doi]
PST - ppublish
SO  - Nestle Nutr Inst Workshop Ser. 2011;69:39-53; discussion 53-8. doi: 
      10.1159/000329281. Epub 2012 Jan 18.