PMID- 22302174
OWN - NLM
STAT- MEDLINE
DCOM- 20120726
LR  - 20120305
IS  - 1364-5528 (Electronic)
IS  - 0003-2654 (Linking)
VI  - 137
IP  - 7
DP  - 2012 Apr 7
TI  - Rapid and on-site analysis of illegal drugs on the nano-microscale using a deep 
      ultraviolet-visible reflected optical fiber sensor.
PG  - 1596-603
LID - 10.1039/c2an15953h [doi]
AB  - A deep ultraviolet-visible (DUV-Vis) reflected optical fiber sensor was developed 
      for use in a simple spectrophotometric detection system to detect the absorption 
      of various illegal drugs at wavelengths between 180 and 800 nm. Quantitative 
      analyses performed using the sensor revealed a high specificity and sensitivity 
      for drug detection at a wavelength of approximately 200 nm. Using a 
      double-absorption optical path length, extremely small sample volumes were used 
      (32 to 160 nL), which allowed the use of minimal amounts of samples. A portable 
      spectrophotometric system was established based on our optical fiber sensor for 
      the on-site determination and quantitative analysis of common illegal drugs, such 
      as 3,4-methylenedioxymethamphetamine (MDMA), ketamine hydrochloride, cocaine 
      hydrochloride, diazepam, phenobarbital, and barbital. By analyzing the absorbance 
      spectra, six different drugs were quantified at concentrations that ranged from 
      0.1 to 1000 mug mL(-1) (16 pg-0.16 mug). A novel Matching Algorithm of Spectra 
      Space (MASS) was used to accurately distinguish between each drug in a mixture. 
      As an important supplement to traditional methods, such as mass spectrometry or 
      chromatography, our optical fiber sensor offers rapid and low-cost on-site 
      detection using trace amounts of sample. This rapid and accurate analytical 
      method has wide-ranging applications in forensic science, law enforcement, and 
      medicine.
FAU - Li, Qiang
AU  - Li Q
AD  - Department of Biomedical Engineering, Tsinghua University School of Medicine, 
      Beijing 100084, China.
FAU - Qiu, Tian
AU  - Qiu T
FAU - Hao, Hongxia
AU  - Hao H
FAU - Zhou, Hong
AU  - Zhou H
FAU - Wang, Tongzhou
AU  - Wang T
FAU - Zhang, Ye
AU  - Zhang Y
FAU - Li, Xin
AU  - Li X
FAU - Huang, Guoliang
AU  - Huang G
FAU - Cheng, Jing
AU  - Cheng J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120203
PL  - England
TA  - Analyst
JT  - The Analyst
JID - 0372652
SB  - IM
MH  - Biosensing Techniques/*instrumentation
MH  - Light
MH  - Nanotechnology
MH  - *Optical Fibers
MH  - Substance Abuse Detection/*instrumentation
MH  - Time Factors
MH  - *Ultraviolet Rays
EDAT- 2012/02/04 06:00
MHDA- 2012/07/27 06:00
CRDT- 2012/02/04 06:00
PHST- 2012/02/04 06:00 [entrez]
PHST- 2012/02/04 06:00 [pubmed]
PHST- 2012/07/27 06:00 [medline]
AID - 10.1039/c2an15953h [doi]
PST - ppublish
SO  - Analyst. 2012 Apr 7;137(7):1596-603. doi: 10.1039/c2an15953h. Epub 2012 Feb 3.