PMID- 22305405
OWN - NLM
STAT- MEDLINE
DCOM- 20130426
LR  - 20211203
IS  - 1873-4847 (Electronic)
IS  - 0955-2863 (Linking)
VI  - 23
IP  - 11
DP  - 2012 Nov
TI  - Regulators of protein metabolism are affected by cyclical nutritional treatments 
      with diets varying in protein and energy content.
PG  - 1467-73
LID - S0955-2863(11)00276-2 [pii]
LID - 10.1016/j.jnutbio.2011.09.009 [doi]
AB  - There is evidence that the E3 ubiquitin ligases muscle ring finger-1 (MuRF1) and 
      atrogin-1, which mediate the ubiquitination of certain proteins and thereby their 
      proteolysis, are regulated by cyclical nutritional treatments varying in lysine 
      content. In order to explore further the regulatory mechanisms involved in 
      metabolic adaptation to dietary changes, we investigated the effects of daily 
      variations in energy [2800 (E-) followed by 3200 kcal/kg (E+)], protein [230 (P+) 
      followed by 150g/kg (P-)] or both [E-P+ followed by E+P-] on muscle protein 
      metabolism in 2-week-old male broiler chickens. Growth performance was similar 
      for all treatments. Expression of atrogin-1 and MuRF1 was changed by alternation 
      of diets varying in protein (higher expression with P- vs. P+) and energy content 
      (higher expression with E- vs. E+). The expression of atrogin-1 was regulated 
      with mixed diets (increase in E+P- vs. E-P+) but not that of MuRF1. Such 
      regulation may involve the mammalian target of rapamycin (mTOR), which was more 
      phosphorylated with P+ than with P-. Eukaryotic initiation factor 4E binding 
      protein, p70S6 kinase and ribosomal protein S6, which are mTOR targets known to 
      control protein synthesis, were highly activated by increased protein content (P+ 
      vs. P-). The mechanisms coordinating the protein synthesis/proteolysis balance 
      remain to be characterized.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Boussaid-Om Ezzine, Sourour
AU  - Boussaid-Om Ezzine S
AD  - INRA, UR83 Recherches Avicoles, F-37380 Nouzilly, France.
FAU - Metayer-Coustard, Sonia
AU  - Metayer-Coustard S
FAU - Collin, Anne
AU  - Collin A
FAU - Rideau, Nicole
AU  - Rideau N
FAU - Leterrier, Christine
AU  - Leterrier C
FAU - Bouvarel, Isabelle
AU  - Bouvarel I
FAU - Seiliez, Iban
AU  - Seiliez I
FAU - Tesseraud, Sophie
AU  - Tesseraud S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120202
PL  - United States
TA  - J Nutr Biochem
JT  - The Journal of nutritional biochemistry
JID - 9010081
RN  - 0 (Dietary Proteins)
RN  - 0 (Eukaryotic Initiation Factor-4E)
RN  - 0 (Muscle Proteins)
RN  - 0 (Proteins)
RN  - 0 (Ribosomal Protein S6)
RN  - EC 2.3.2.27 (SKP Cullin F-Box Protein Ligases)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
RN  - EC 2.7.11.1 (Ribosomal Protein S6 Kinases, 90-kDa)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - *Animal Nutritional Physiological Phenomena
MH  - Animals
MH  - Chickens/metabolism/*physiology
MH  - *Diet
MH  - Dietary Proteins/*pharmacology
MH  - Energy Intake
MH  - Eukaryotic Initiation Factor-4E/genetics
MH  - Male
MH  - Muscle Proteins/metabolism
MH  - Muscle, Skeletal/drug effects/growth & development/metabolism
MH  - Phosphorylation
MH  - Protein Biosynthesis
MH  - Proteins/*metabolism
MH  - Ribosomal Protein S6/genetics
MH  - Ribosomal Protein S6 Kinases, 90-kDa/genetics
MH  - SKP Cullin F-Box Protein Ligases/metabolism
MH  - TOR Serine-Threonine Kinases/metabolism
MH  - Ubiquitin-Protein Ligases/metabolism
EDAT- 2012/02/07 06:00
MHDA- 2013/04/27 06:00
CRDT- 2012/02/07 06:00
PHST- 2011/05/03 00:00 [received]
PHST- 2011/09/12 00:00 [revised]
PHST- 2011/09/22 00:00 [accepted]
PHST- 2012/02/07 06:00 [entrez]
PHST- 2012/02/07 06:00 [pubmed]
PHST- 2013/04/27 06:00 [medline]
AID - S0955-2863(11)00276-2 [pii]
AID - 10.1016/j.jnutbio.2011.09.009 [doi]
PST - ppublish
SO  - J Nutr Biochem. 2012 Nov;23(11):1467-73. doi: 10.1016/j.jnutbio.2011.09.009. Epub 
      2012 Feb 2.