PMID- 2230542
OWN - NLM
STAT- MEDLINE
DCOM- 19901210
LR  - 20061115
IS  - 0022-2143 (Print)
IS  - 0022-2143 (Linking)
VI  - 116
IP  - 5
DP  - 1990 Nov
TI  - Serum immunoglobulins E and G anti-Aspergillus fumigatus antibody in patients 
      with cystic fibrosis who have allergic bronchopulmonary aspergillosis.
PG  - 724-7
AB  - Patients with cystic fibrosis frequently have pulmonary colonization with 
      Aspergillus fumigatus (Af) and develop anti-Af immunoglobulin E (IgE) and IgG 
      antibodies. The diagnosis of allergic bronchopulmonary aspergillosis in subjects 
      with cystic fibrosis is difficult because of the high incidence of Af 
      colonization, with development of humoral antibody responses. In this study, we 
      sequentially measured serum anti-Af IgE (Af-E) and IgG (Af-G) antibodies by ELISA 
      in subjects with cystic fibrosis. In subjects with cystic fibrosis who have 
      allergic bronchopulmonary aspergillosis, Af-E and Af-G antibodies were 
      significantly increased when compared with other groups of patients with cystic 
      fibrosis who had positive skin tests or precipitins to Af (or both) (p less than 
      0.01, p less than 0.01, respectively). In addition, increased Af-E and Af-G 
      levels were sometimes seen in other groups, especially subjects with cystic 
      fibrosis who had positive Af skin tests or precipitin tests, two of whom later 
      developed criteria diagnostic of allergic bronchopulmonary aspergillosis. Thus, 
      serum Af-E and Af-G levels were quantitatively increased in subjects with cystic 
      fibrosis who had allergic bronchopulmonary aspergillosis and thus adjunctive data 
      in diagnosis. However, it also suggested that subclinical pulmonary inflammation 
      may also occur.
FAU - Knutsen, A P
AU  - Knutsen AP
AD  - Department of Pediatrics and Internal Medicine, St. Louis University Medical 
      Center, MO 63104.
FAU - Hutcheson, P S
AU  - Hutcheson PS
FAU - Mueller, K R
AU  - Mueller KR
FAU - Slavin, R G
AU  - Slavin RG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Lab Clin Med
JT  - The Journal of laboratory and clinical medicine
JID - 0375375
RN  - 0 (Antibodies, Fungal)
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Antibodies, Fungal/*blood
MH  - Aspergillosis, Allergic Bronchopulmonary/complications/*diagnosis/immunology
MH  - Aspergillus fumigatus/*immunology
MH  - Child
MH  - Cystic Fibrosis/*complications/immunology
MH  - Humans
MH  - Immunoglobulin E/*analysis
MH  - Immunoglobulin G/*analysis
MH  - Precipitin Tests
MH  - Skin Tests
EDAT- 1990/11/01 00:00
MHDA- 1990/11/01 00:01
CRDT- 1990/11/01 00:00
PHST- 1990/11/01 00:00 [pubmed]
PHST- 1990/11/01 00:01 [medline]
PHST- 1990/11/01 00:00 [entrez]
PST - ppublish
SO  - J Lab Clin Med. 1990 Nov;116(5):724-7.