PMID- 22306455
OWN - NLM
STAT- MEDLINE
DCOM- 20120830
LR  - 20181201
IS  - 1090-2139 (Electronic)
IS  - 0889-1591 (Linking)
VI  - 26
IP  - 4
DP  - 2012 May
TI  - Immunological parameters in elderly women: correlations with aerobic power, 
      muscle strength and mood state.
PG  - 597-606
LID - 10.1016/j.bbi.2012.01.012 [doi]
AB  - PURPOSE: Our objective was to relate immunological data for healthy but sedentary 
      elderly women to aerobic power, strength, and mood state. METHODS: We measured 
      peak aerobic power and one-repetition maximum strength along with mood 
      (depression and fatigue), quality of life and carbohydrate intake on 42 women 
      aged 60-77 years. Standard immunological techniques determined natural killer 
      cell count and cytotoxic activity (NKCA), proliferative responses to 
      phytohemaglutinin and OKT(3), various lymphocyte subpopulations (CD3(+), 
      CD3(-)CD19(+), CD56(+), CD4(+), CD8(+), CD56(dim) and CD56(bright)), and markers 
      of activation, maturation, down-regulation and susceptibility to apoptosis 
      (CD25(+), CD28(+), CD45RA(+), CD45RO(+), CD69(+), CD95(+), HLA-DR(+)). RESULTS: 
      Correlations of immune parameters with aerobic power and strength were very 
      similar for absolute and relative immunological data. In the group as a whole, 
      the only correlation with aerobic power was -0.35 (relative CD4(+)CD69(+) count), 
      but in subjects with values <22.6 mL kg(-1)min(-1) correlations ranged from -0.57 
      (relative CD4(+)CD45RO(+)) to 0.92 (absolute CD56(dim)HLA-DR(+)). In terms of 
      muscle strength, univariate correlation coefficients ranged from -0.34 (relative 
      and absolute CD3(+)CD4(+)CD8(+)) to +0.48 (absolute CD3(+)HLA-DR(+)) and +0.50 
      (absolute CD8(+)CD45RA(+)CD45RO(+)). Neither NKCA nor lymphocyte proliferation 
      were correlated with aerobic power or muscle strength. Although mood state and 
      quality of life can sometimes be influenced by an individual's fitness level, our 
      multivariate analyses suggested that depression, fatigue and quality of life were 
      more important determinants of immune profile than our fitness measures. 
      CONCLUSIONS: Psychological changes associated with aging may have a substantial 
      adverse effect upon the immune system, and immunological function may be enhanced 
      more by addressing these issues than by focusing upon aerobic or resistance 
      training.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Raso, Vagner
AU  - Raso V
AD  - Department of Experimental Pathophysiology, Medical School of the University of 
      Sao Paulo, FMUSP, Brazil. vraso@usp.br
FAU - Natale, Valeria Maria
AU  - Natale VM
FAU - Duarte, Alberto Jose da Silva
AU  - Duarte AJ
FAU - Greve, Julia Maria D'Andrea
AU  - Greve JM
FAU - Shephard, Roy J
AU  - Shephard RJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120128
PL  - Netherlands
TA  - Brain Behav Immun
JT  - Brain, behavior, and immunity
JID - 8800478
SB  - IM
MH  - Affect
MH  - Aged
MH  - Aging/*immunology
MH  - Depression/*immunology
MH  - Fatigue/*immunology
MH  - Female
MH  - Humans
MH  - Lymphocyte Activation/immunology
MH  - Lymphocyte Subsets/*immunology
MH  - Lymphocytes/*immunology
MH  - Middle Aged
MH  - Muscle Strength/*immunology
MH  - Quality of Life
MH  - Sedentary Behavior
EDAT- 2012/02/07 06:00
MHDA- 2012/08/31 06:00
CRDT- 2012/02/07 06:00
PHST- 2011/09/22 00:00 [received]
PHST- 2011/12/23 00:00 [revised]
PHST- 2012/01/18 00:00 [accepted]
PHST- 2012/02/07 06:00 [entrez]
PHST- 2012/02/07 06:00 [pubmed]
PHST- 2012/08/31 06:00 [medline]
AID - S0889-1591(12)00014-1 [pii]
AID - 10.1016/j.bbi.2012.01.012 [doi]
PST - ppublish
SO  - Brain Behav Immun. 2012 May;26(4):597-606. doi: 10.1016/j.bbi.2012.01.012. Epub 
      2012 Jan 28.